Title:
COMPOSITION FOR LOWERING BLOOD GLUCOSE LEVEL, REDUCING BLOOD HEMOGLOBIN A1c CONTENT, OR INCREASING BLOOD HDL-CHOLESTEROL CONTENT
Document Type and Number:
WIPO Patent Application WO/2021/002335
Kind Code:
A1
Abstract:
One or more embodiments of the present invention provide a composition for improving lipid metabolism or carbohydrate metabolism, said composition containing a component derived from turmeric. One or more embodiments of the present invention pertain to a composition for lowering blood glucose level, reducing blood hemoglobin A1c content or increasing blood HDL-cholesterol content, a composition for treating or preventing metabolic syndrome or a composition for improving lipid metabolism or carbohydrate metabolism, said composition containing at least one selected from turmeronol A, turmeronol B and bisacurone as an active ingredient. The aforesaid composition can contain turmeronol A and turmeronol B in a total amount of 20 μg or more per daily intake, turmeronol A in an amount of 17 μg or more per daily intake, turmeronol B in an amount of 5 μg or more per daily intake, and bisacurone in an amount of 80 μg or more per daily intake.
Inventors:
UCHIO RYUSEI (JP)
MUROYAMA KOUTAROU (JP)
KAWASAKI KENGO (JP)
MUROSAKI SHINJI (JP)
MUROYAMA KOUTAROU (JP)
KAWASAKI KENGO (JP)
MUROSAKI SHINJI (JP)
Application Number:
PCT/JP2020/025571
Publication Date:
January 07, 2021
Filing Date:
June 29, 2020
Export Citation:
Assignee:
HOUSE WELLNESS FOODS CORP (JP)
International Classes:
A61P3/04; A61K31/122; A61K36/9066; A61P3/06; A61P3/10; A61P9/10
Domestic Patent References:
| WO2002047699A1 | 2002-06-20 | |||
| WO2019087278A1 | 2019-05-09 |
Other References:
MOHANKUMAR, S. ET AL.: "An aqueous extract of Curcuma longa (turmeric) rhizomes stimulates insulin release and mimics insulin action on tissues involved in glucose homeostasis in vitro", PHYTOTHERAPY RESEARCH, vol. 25, no. 3, 2011, pages 396 - 401, XP018503532, DOI: 10.1002/ptr.3275
KASABRI, V. ET AL.: "In vitro modulation of pancreatic insulin secretion, extrapancreatic insulin action and peptide glycation by Curcuma longa aqueous extracts", JOURNAL OF EXPERIMENTAL AND INTEGRATIVE MEDICINE, vol. 4, no. 3, 2014, pages 187 - 193, XP055783855, DOI: 10.5455/jeim.170414.or.101
CURCUMA LONGA LINN, vol. 54, no. 2, 2014, pages 13 - 18
M. HALIM, ESHRAT ET AL.: "Hypoglycemic, hypolipidemic and antioxidant properties of combination of Curcumin from Curcuma longa, Linn, and partially purified product from Abroma augusta , Linn. in streptozotocin induced diabetes", INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY, vol. 17, no. 2, 2002, pages 33 - 43, XP055219220
MUSTAFA, SODAH B. ET AL.: "Antihyperglycemic Activity of Hydroalcoholic Extracts of Selective Medicinal Plants Curcuma longa, Lavandula stoechas, Aegle marmelos, and Glycyrrhiza glabra and Their Polyherbal Preparation in Alloxan-Induced Diabetic Mice", DOSE-RESPONSE, vol. 17, no. 2, 2019, XP055783859, DOI: 10.1177/1559325819852503
IMAI, S. ET AL.: "Turmeronol A and Turmeronol B, New Inhibitors of Soybean Lipoxygenase", AGRICULTURAL AND BIOLOGICAL CHEMISTRY, vol. 54, no. 9, 1990, pages 2367 - 2371, XP055783861
TSUJITA, MAKI ET AL.: "Exposure to High Glucose Concentration Decreases Cell Surface ABCA1 and HDL Biogenesis in Hepatocytes", JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, vol. 24, no. 11, 2017, pages 1132 - 1149, XP055783850
JUNG, M. A. ET AL.: "Hypocholesterolemic effects of Curcuma longa L. with Nelumbo nucifera leaf in an in vitro model and a high cholesterol diet- induced hypercholesterolemic mouse model", ANIMAL CELLS AND SYSTEMS, vol. 19, no. 2, 2015, pages 133 - 143, XP055783863
YIU, W.-F. ET AL.: "Attenuation of fatty liver and prevention of hypercholesterolemia by extract of Curcuma longa through regulating the expression of CYP7A1, LDL-receptor, HO-1, and HMG-CoA reductase", JOURNAL OF FOOD SCIENCE, vol. 76, no. 3, 2011, pages 133 - 143, XP055385099, DOI: 10.1111/j.1750-3841.2011.02042.x
UCHIO, R. ET AL.: "Hot water extract of Curcuma longa L. improves serum inflammatory markers and general health in subjects with overweight or prehypertension/mild hypertension: a randomized, double-blind, placebo- controlled trial", NUTRIENTS, vol. 11, no. 8, 7 August 2019 (2019-08-07), XP055783866, DOI: 10.3390/nul1081822
KASABRI, V. ET AL.: "In vitro modulation of pancreatic insulin secretion, extrapancreatic insulin action and peptide glycation by Curcuma longa aqueous extracts", JOURNAL OF EXPERIMENTAL AND INTEGRATIVE MEDICINE, vol. 4, no. 3, 2014, pages 187 - 193, XP055783855, DOI: 10.5455/jeim.170414.or.101
CURCUMA LONGA LINN, vol. 54, no. 2, 2014, pages 13 - 18
M. HALIM, ESHRAT ET AL.: "Hypoglycemic, hypolipidemic and antioxidant properties of combination of Curcumin from Curcuma longa, Linn, and partially purified product from Abroma augusta , Linn. in streptozotocin induced diabetes", INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY, vol. 17, no. 2, 2002, pages 33 - 43, XP055219220
MUSTAFA, SODAH B. ET AL.: "Antihyperglycemic Activity of Hydroalcoholic Extracts of Selective Medicinal Plants Curcuma longa, Lavandula stoechas, Aegle marmelos, and Glycyrrhiza glabra and Their Polyherbal Preparation in Alloxan-Induced Diabetic Mice", DOSE-RESPONSE, vol. 17, no. 2, 2019, XP055783859, DOI: 10.1177/1559325819852503
IMAI, S. ET AL.: "Turmeronol A and Turmeronol B, New Inhibitors of Soybean Lipoxygenase", AGRICULTURAL AND BIOLOGICAL CHEMISTRY, vol. 54, no. 9, 1990, pages 2367 - 2371, XP055783861
TSUJITA, MAKI ET AL.: "Exposure to High Glucose Concentration Decreases Cell Surface ABCA1 and HDL Biogenesis in Hepatocytes", JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, vol. 24, no. 11, 2017, pages 1132 - 1149, XP055783850
JUNG, M. A. ET AL.: "Hypocholesterolemic effects of Curcuma longa L. with Nelumbo nucifera leaf in an in vitro model and a high cholesterol diet- induced hypercholesterolemic mouse model", ANIMAL CELLS AND SYSTEMS, vol. 19, no. 2, 2015, pages 133 - 143, XP055783863
YIU, W.-F. ET AL.: "Attenuation of fatty liver and prevention of hypercholesterolemia by extract of Curcuma longa through regulating the expression of CYP7A1, LDL-receptor, HO-1, and HMG-CoA reductase", JOURNAL OF FOOD SCIENCE, vol. 76, no. 3, 2011, pages 133 - 143, XP055385099, DOI: 10.1111/j.1750-3841.2011.02042.x
UCHIO, R. ET AL.: "Hot water extract of Curcuma longa L. improves serum inflammatory markers and general health in subjects with overweight or prehypertension/mild hypertension: a randomized, double-blind, placebo- controlled trial", NUTRIENTS, vol. 11, no. 8, 7 August 2019 (2019-08-07), XP055783866, DOI: 10.3390/nul1081822
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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