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Patent Searching and Data


Title:
COMPOSITION FOR MEDIUM
Document Type and Number:
WIPO Patent Application WO/2021/106698
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel composition which is for a medium and can be used to induce differentiation from somatic cells into brown adipocytes. For example, the present invention may be a composition which is for a differentiation-inducing medium and is used to induce differentiation from somatic cells into brown adipocytes, the composition being characterized by containing seven components: a thyroid hormone receptor agonist; a glucocorticoid receptor agonist; a phosphodiesterase inhibitor; insulin; an ascorbic acid derivative; albumin; and an antibiotic. According to the present invention, the differentiation of somatic cells into brown adipocytes can be effectively induced. Moreover, according to the present invention, the brown adipocytes can be effectively maintained.

Inventors:
DAI PING (JP)
TAKEDA YUKIMASA (JP)
HARADA YOSHINORI (JP)
MATSUMOTO JUNICHI (JP)
Application Number:
PCT/JP2020/042899
Publication Date:
June 03, 2021
Filing Date:
November 18, 2020
Export Citation:
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Assignee:
KATAOKA CORP (JP)
KYOTO PREFECTURAL PUBLIC UNIV CORP (JP)
International Classes:
C12N5/077
Domestic Patent References:
WO2018062269A12018-04-05
WO2017009263A12017-01-19
WO2017026462A12017-02-16
Other References:
TAKEDA, Y. ET AL.: "Direct conversion of human fibroblasts to brown adipocytes by small chemical compounds", SCIENTIFIC REPORTS, vol. 7, no. 4304, 27 June 2017 (2017-06-27), pages 1 - 11, XP055513869, DOI: 10.1038/s41598-017-04665-x
Attorney, Agent or Firm:
SHIMIZU Naoto (JP)
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