Title:
COMPOSITION AND METHOD FOR REGULATING MIGRATION OF IMMUNE CELLS
Document Type and Number:
WIPO Patent Application WO/2020/103789
Kind Code:
A1
Abstract:
A composition and method for regulating the migration of immune cells. The method for regulating the migration of immune cells comprises the step of strengthening or weakening the interaction between Hsp90 and α4 integrin in immune cells. Also provided is an immune cell capable of strengthening or weakening the interaction between Hsp90 and α4 integrin and a pharmaceutical composition thereof. The present method and pharmaceutical composition may be used to treat pathogen infections and autoimmune diseases or to kill tumor cells.
More Like This:
| WO2005117994 | BMP PATHWAY METHODS AND COMPOSITIONS |
| WO/2002/041922 | METHOD OF REGULATING THE ACTIVITY OF EXPRESSION PRODUCT OF GENE TRANSFERRED INTO LIVING BODY |
| WO/2002/012341 | HER-2/NEU FUSION PROTEINS |
Inventors:
CHEN JIANFENG (CN)
LIN CHANGDONG (CN)
LIN CHANGDONG (CN)
Application Number:
PCT/CN2019/119171
Publication Date:
May 28, 2020
Filing Date:
November 18, 2019
Export Citation:
Assignee:
CENTER FOR EXCELLENCE IN MOLECULAR CELL SCIENCE CHINESE ACAD OF SCIENCES (CN)
International Classes:
C07K14/71; A61K38/00; A61P37/00; A61P37/02; C07K14/47
Domestic Patent References:
| WO2005009350A2 | 2005-02-03 |
Foreign References:
| CN105793421A | 2016-07-20 | |||
| CN1718243A | 2006-01-11 | |||
| CN1652789A | 2005-08-10 | |||
| CN1860132A | 2006-11-08 | |||
| CN103619874A | 2014-03-05 |
Other References:
MELISSA MILLARD, SRINIVAS ODDE, NOURI NEAMATI: "Integrin Targeted Therapeutics", THERANOSTICS, vol. 1, 17 February 2011 (2011-02-17), pages 154 - 188, XP002675313, ISSN: 1838-7640, DOI: 10.7150/thno/v01p0154
SREYASHI BASU, PRAMOD K. SRIVASTAVA: "Fever-like Temperature Induces Maturation of Dendritic Cells through Induction of Hsp90", INTERNATIONAL IMMUNOLOGY, vol. 15, no. 9, 1 September 2003 (2003-09-01), pages 1053 - 1061, XP002979688, ISSN: 0953-8178, DOI: 10.1093/intimm/dxg104
JING REN, BI-BO YAN, FENG SHI, BING XIONG, JING-KANG SHEN: "Progress in the Study of Small Molecule Inhibitors of HSP90", ACTA PHARMACEUTICA SINICA, vol. 50, no. 6, 30 June 2015 (2015-06-30), pages 640 - 649, XP055819528, ISSN: 0513-4870
SHANIQUE A. YOUNG, KATELYN E. MCCABE, ALENA BARTAKOVA, JOE DELANEY, DONALD P. PIZZO, ROBERT O. NEWBURY, JUDITH A. VARNER, DAVID D.: "Integrin a4 Enhances Metastasis and May Be Associated with Poor Prognosis in MYCNlow Neuroblastoma", PLOS ONE, vol. 10, no. 5, e0120815, 14 May 2015 (2015-05-14), pages 1 - 17, XP055514523, DOI: 10.1371/journal.pone.0120815
DAVID M. ROSE, SHOUCHUN LIU, DARREN G. WOODSIDE, JAEWON HAN, DAVID D. SCHLAEPFER, MARK H. GINSBERG: "Paxillin Binding to the a4 Integrin Subunit Stimulates LFA-1 (Integrin aL(32)-Dependent T Cell Migration by Augmenting the Activation of Focal Adhesion Kinase/ Proline-Rich Tyrosine Kinase-2", THE JOURNAL OF IMMUNOLOGY, vol. 170, no. 12, 15 June 2003 (2003-06-15), pages 5912 - 5918, XP055711085, ISSN: 0022-1767, DOI: 10.4049/jimmunol.170.12.5912
LIN CHANGDONG, ZHANG YOUHUA, ZHANG KUN, ZHENG YAJUAN, LU LING, CHANG HAISHUANG, YANG HUI, YANG YANRONG, WAN YAOYING, WANG SHIHUI, : "Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and a4 Integrins", IMMUNITY, vol. 50, no. 1, 25 April 2020 (2020-04-25), AMSTERDAM, NL, pages 137 - 151.e6, XP009528409, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2018.11.013
S. S. EVANS, M. D. BAIN, W. C. WANG: "Fever-Range Hyperthermia Stimulates Alpha4beta7 Integrin-dependent Lymphocyte-endothelial Adhesion", INTERNATIONAL JOURNAL OF HYPERTHERMIA, vol. 16, no. 1, 1 January 2000 (2000-01-01), pages 45 - 59, XP055711084, ISSN: 0265-6736, DOI: 10.1080/026567300285411
See also references of EP 3885358A4
SREYASHI BASU, PRAMOD K. SRIVASTAVA: "Fever-like Temperature Induces Maturation of Dendritic Cells through Induction of Hsp90", INTERNATIONAL IMMUNOLOGY, vol. 15, no. 9, 1 September 2003 (2003-09-01), pages 1053 - 1061, XP002979688, ISSN: 0953-8178, DOI: 10.1093/intimm/dxg104
JING REN, BI-BO YAN, FENG SHI, BING XIONG, JING-KANG SHEN: "Progress in the Study of Small Molecule Inhibitors of HSP90", ACTA PHARMACEUTICA SINICA, vol. 50, no. 6, 30 June 2015 (2015-06-30), pages 640 - 649, XP055819528, ISSN: 0513-4870
SHANIQUE A. YOUNG, KATELYN E. MCCABE, ALENA BARTAKOVA, JOE DELANEY, DONALD P. PIZZO, ROBERT O. NEWBURY, JUDITH A. VARNER, DAVID D.: "Integrin a4 Enhances Metastasis and May Be Associated with Poor Prognosis in MYCNlow Neuroblastoma", PLOS ONE, vol. 10, no. 5, e0120815, 14 May 2015 (2015-05-14), pages 1 - 17, XP055514523, DOI: 10.1371/journal.pone.0120815
DAVID M. ROSE, SHOUCHUN LIU, DARREN G. WOODSIDE, JAEWON HAN, DAVID D. SCHLAEPFER, MARK H. GINSBERG: "Paxillin Binding to the a4 Integrin Subunit Stimulates LFA-1 (Integrin aL(32)-Dependent T Cell Migration by Augmenting the Activation of Focal Adhesion Kinase/ Proline-Rich Tyrosine Kinase-2", THE JOURNAL OF IMMUNOLOGY, vol. 170, no. 12, 15 June 2003 (2003-06-15), pages 5912 - 5918, XP055711085, ISSN: 0022-1767, DOI: 10.4049/jimmunol.170.12.5912
LIN CHANGDONG, ZHANG YOUHUA, ZHANG KUN, ZHENG YAJUAN, LU LING, CHANG HAISHUANG, YANG HUI, YANG YANRONG, WAN YAOYING, WANG SHIHUI, : "Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and a4 Integrins", IMMUNITY, vol. 50, no. 1, 25 April 2020 (2020-04-25), AMSTERDAM, NL, pages 137 - 151.e6, XP009528409, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2018.11.013
S. S. EVANS, M. D. BAIN, W. C. WANG: "Fever-Range Hyperthermia Stimulates Alpha4beta7 Integrin-dependent Lymphocyte-endothelial Adhesion", INTERNATIONAL JOURNAL OF HYPERTHERMIA, vol. 16, no. 1, 1 January 2000 (2000-01-01), pages 45 - 59, XP055711084, ISSN: 0265-6736, DOI: 10.1080/026567300285411
See also references of EP 3885358A4
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
Download PDF:
Previous Patent: APPLICATION OF CHIDAMIDE IN COMBINATION WITH R-CHOP, AND DRUG COMBINATION
Next Patent: INTEGRATED WASHER DRYER
Next Patent: INTEGRATED WASHER DRYER