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Patent Searching and Data


Title:
COMPOSITION FOR MODIFYING TARGET GENE
Document Type and Number:
WIPO Patent Application WO/2019/131829
Kind Code:
A1
Abstract:
A delivery method is provided which delivers a gene modifying tool which achieves a high gene modification efficiency in cells. This composition, for inducing genetic modification in a target locus in a cell, contains 1) the compound represented by expression (I) or a salt thereof, 2) structural lipids, and 3) guide RNA or DNA containing a sequence encoding this, and/or RNA-guided nuclease, or nucleic acids including a sequence encoding this. In expression (I), n is an integer 2-5, R is a linear C1-5 alkyl group, a linear C7-11 alkenyl group or a linear C11 alkadienyl group, the wavy lines independently represent cis or trans bonds.

Inventors:
HOTTA AKITSU (JP)
IFUKU MASATAKA (JP)
FUJIMOTO NAOKO (JP)
IWABUCHI KUMIKO (JP)
KENJO ERIYA (JP)
MAKITA YUKIMASA (JP)
OCHIAI RUMIKO (JP)
Application Number:
PCT/JP2018/048034
Publication Date:
July 04, 2019
Filing Date:
December 27, 2018
Export Citation:
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Assignee:
UNIV KYOTO (JP)
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
C12N15/09; A01K67/027; A61K31/7088; A61K38/46; A61K47/18; A61K47/24; A61K47/28; A61K48/00; A61P21/02; A61P43/00; C07K14/435; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12
Domestic Patent References:
WO2016197133A12016-12-08
WO2016197133A12016-12-08
WO2016025469A12016-02-18
WO2014197748A22014-12-11
Foreign References:
CN104116643A2014-10-29
Other References:
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Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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