Title:
COMPOSITION FOR PREVENTING, ALLEVIATING, OR TREATING CANCER, COMPRISING PERILLA-LEAF-DERIVED NANOVESICLE AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2022/234922
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing, alleviating, or treating cancer, comprising a perilla-leaf-derived nanovesicle as an active ingredient. A perilla-leaf-derived nanovesicle of the present invention is a natural compound derived from leaves of Perilla frutescens, a plant of the genus Perilla, is advantageous in that the nanovesicle has better biocompatibility and stability and higher cell permeability than those of animal-derived substances, and is non-toxic to normal human cells to inhibit cancer cell proliferation by selectively attacking only specific cancer cells of breast cancer or cervical cancer while minimizing side effects, and thus is effectively usable in the treatment, alleviation, or prevention of cancer.
Inventors:
RHEE WON JONG (KR)
KIM DO KYUNG (KR)
KIM DO KYUNG (KR)
Application Number:
PCT/KR2021/020296
Publication Date:
November 10, 2022
Filing Date:
December 30, 2021
Export Citation:
Assignee:
INCHEON NATIONAL UNIV RESEARCH ＆ BUSINESS FOUNDATION (KR)
International Classes:
A61K36/535; A23L33/105; A61K8/9789; A61P35/00; A61Q19/00
Foreign References:
| KR20200121062A | 2020-10-23 | |||
| KR20170037380A | 2017-04-04 |
Other References:
TOSHIHIRO AKIHISA ; SATOSHI KAMO ; TAKETO UCHIYAMA ; HIROYUKI AKAZAWA ; NORIHIRO BANNO ; YOSUKE TAGUCHI ; KEN YASUKAWA: "Cytotoxic activity of Perilla frutescens var. japonica leaf extract is due to high concentrations of oleanolic and ursolic acids", JOURNAL OF NATURAL MEDICINES, SPRINGER-VERLAG, TO, vol. 60, no. 4, 15 August 2006 (2006-08-15), To , pages 331 - 333, XP019411444, ISSN: 1861-0293, DOI: 10.1007/s11418-006-0015-9
KOMSAK PINTHA, PAYUNGSAK TANTIPAIBOONWONG, SUPACHAI YODKEEREE, WITTAYA CHAIWANGYEN, ORADA CHUMPHUKAM, ORAWAN KHANTAMAT, CHAKKRIT K: "Thai perilla (Perilla frutescens) leaf extract inhibits human breast cancer invasion and migration", MAEJO INTERNATIONAL JOURNAL OF SCIENCE AND TECHNOLOGY, MAEJO UNIVERSITY, TH, vol. 12, no. 2, 15 May 2018 (2018-05-15), TH , pages 112 - 123, XP009540846, ISSN: 1905-7873
ALFIERI MARIAEVELINA, LEONE ANTONIETTA, AMBROSONE ALFREDO: "Plant-Derived Nano and Microvesicles for Human Health and Therapeutic Potential in Nanomedicine", PHARMACEUTICS, vol. 13, no. 4, pages 498, XP055982993, DOI: 10.3390/pharmaceutics13040498
KIM, D. K. et al. O109: Isolation and Investigation of Plant-derived Extracellular Vesicles as Novel Therapeutic Nanobiomaterials. In: 2021 한국생물공학회 추계학술발표대회 및 국제심포지엄. 06 October-09 October 2021. 경주화백컨벤션센터 (2021 KSBB Fall Meeting and International Symposium. Gyeongju Hwabaek International Convention Center.)
KOMSAK PINTHA, PAYUNGSAK TANTIPAIBOONWONG, SUPACHAI YODKEEREE, WITTAYA CHAIWANGYEN, ORADA CHUMPHUKAM, ORAWAN KHANTAMAT, CHAKKRIT K: "Thai perilla (Perilla frutescens) leaf extract inhibits human breast cancer invasion and migration", MAEJO INTERNATIONAL JOURNAL OF SCIENCE AND TECHNOLOGY, MAEJO UNIVERSITY, TH, vol. 12, no. 2, 15 May 2018 (2018-05-15), TH , pages 112 - 123, XP009540846, ISSN: 1905-7873
ALFIERI MARIAEVELINA, LEONE ANTONIETTA, AMBROSONE ALFREDO: "Plant-Derived Nano and Microvesicles for Human Health and Therapeutic Potential in Nanomedicine", PHARMACEUTICS, vol. 13, no. 4, pages 498, XP055982993, DOI: 10.3390/pharmaceutics13040498
KIM, D. K. et al. O109: Isolation and Investigation of Plant-derived Extracellular Vesicles as Novel Therapeutic Nanobiomaterials. In: 2021 한국생물공학회 추계학술발표대회 및 국제심포지엄. 06 October-09 October 2021. 경주화백컨벤션센터 (2021 KSBB Fall Meeting and International Symposium. Gyeongju Hwabaek International Convention Center.)
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
Download PDF: