Title:
COMPOSITION FOR PREVENTING OR TREATING DETERIORATION IN BRAIN FUNCTION OR MAINTAINING OR IMPROVING BRAIN FUNCTION
Document Type and Number:
WIPO Patent Application WO/2022/118944
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing: a method for evaluating dementia; and a composition for preventing or treating deterioration in brain function, or maintaining or improving brain function. The intestinal microflora of healthy people, people with mild cognitive impairment, or patients suffering from Alzheimer's disease were compared. As a result, a microorganism belonging to the genus Faecalibacterium was selected as an intestinal microorganism associated with cognitive function. Furthermore, it has been found that Faecalibacterium prausnitzii having a specific DNA exhibits an effect of ameliorating brain function deterioration such as learning and memory impairment.
More Like This:
Inventors:
SHINKAI SHOJI (JP)
KITAMURA AKIHIKO (JP)
YAMADA TAKUJI (JP)
USHIDA KAZUNARI (JP)
TSUCHIDA SAYAKA (JP)
UEDA ATSUSHI (JP)
KOUDA NORIYUKI (JP)
KARIYA TAKAHIRO (JP)
KAWAHARA TOMOHIRO (JP)
KOBAYASHI YODAI (JP)
KITAMURA AKIHIKO (JP)
YAMADA TAKUJI (JP)
USHIDA KAZUNARI (JP)
TSUCHIDA SAYAKA (JP)
UEDA ATSUSHI (JP)
KOUDA NORIYUKI (JP)
KARIYA TAKAHIRO (JP)
KAWAHARA TOMOHIRO (JP)
KOBAYASHI YODAI (JP)
Application Number:
PCT/JP2021/044393
Publication Date:
June 09, 2022
Filing Date:
December 03, 2021
Export Citation:
Assignee:
OTSUKA PHARMA CO LTD (JP)
TOKYO INST TECH (JP)
TOKYO INST TECH (JP)
International Classes:
A61P25/28; A23L33/135; A61K35/74; A61K35/741; C12N1/20; C12Q1/02; C12Q1/04
Other References:
SUN JING, XU JINGXUAN, LING YI, WANG FANGYAN, GONG TIANYU, YANG CHANGWEI, YE SHIQING, YE KEYUE, WEI DIANHUI, SONG ZIQING, CHEN DAN: "Fecal microbiota transplantation alleviated Alzheimer’s disease-like pathogenesis in APP/PS1 transgenic mice", TRANSLATIONAL PSYCHIATRY, vol. 9, no. 1, 1 December 2019 (2019-12-01), XP055774506, DOI: 10.1038/s41398-019-0525-3
HAO ZIKAI; WANG WEI; GUO RONG; LIU HONG: "Faecalibacterium prausnitzii(ATCC 27766) has preventive and therapeutic effects on chronic unpredictable mild stress-induced depression-like and anxiety-like behavior in rats", PSYCHONEUROENDOCRINOLOGY., OXFORD, GB, vol. 104, 1 January 1900 (1900-01-01), GB , pages 132 - 142, XP085669153, ISSN: 0306-4530, DOI: 10.1016/j.psyneuen.2019.02.025
REN TENGZHU, GAO YUYUAN, QIU YIHUI, JIANG SHUOLIN, ZHANG QINGXI, ZHANG JIAHUI, WANG LIMIN, ZHANG YUHU, WANG LIJUAN, NIE KUN: "Gut Microbiota Altered in Mild Cognitive Impairment Compared With Normal Cognition in Sporadic Parkinson's Disease", FRONTIERS IN NEUROLOGY, vol. 11, XP055936044, DOI: 10.3389/fneur.2020.00137
CATTANEO ANNAMARIA; CATTANE NADIA; GALLUZZI SAMANTHA; PROVASI STEFANIA; LOPIZZO NICOLA; FESTARI CRISTINA; FERRARI CLARISSA; GUERRA: "Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly", NEUROBIOLOGY OF AGING, TARRYTOWN, NY, US, vol. 49, 31 August 2016 (2016-08-31), US , pages 60 - 68, XP029828461, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2016.08.019
HARAN JOHN P., BHATTARAI SHAKTI K., FOLEY SAGE E., DUTTA PROTIVA, WARD DOYLE V., BUCCI VANNI, MCCORMICK BETH A.: "Alzheimer’s Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway", MBIO, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 10, no. 3, 25 June 2019 (2019-06-25), US , XP055936063, ISSN: 2161-2129, DOI: 10.1128/mBio.00632-19
LIU PING, WU LI, PENG GUOPING, HAN YUQIU, TANG RUIQI, GE JIANPING, ZHANG LIJIANG, JIA LONGFEI, YUE SIQING, ZHOU KAI, LI LANJUAN, L: "Altered microbiomes distinguish Alzheimer’s disease from amnestic mild cognitive impairment and health in a Chinese cohort", BRAIN, BEHAVIOR AND IMMUNITY., ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 80, 1 August 2019 (2019-08-01), US , pages 633 - 643, XP055936070, ISSN: 0889-1591, DOI: 10.1016/j.bbi.2019.05.008
UEDA ATSUSHI, SHINKAI SHOJI, SHIROMA HIROTSUGU, TANIGUCHI YU, TSUCHIDA SAYAKA, KARIYA TAKAHIRO, KAWAHARA TOMOHIRO, KOBAYASHI YODAI: "Identification of Faecalibacterium prausnitzii strains for gut microbiome-based intervention in Alzheimer’s-type dementia", CELL REPORTS MEDICINE, vol. 2, no. 9, 1 September 2021 (2021-09-01), pages 100398, XP055936073, ISSN: 2666-3791, DOI: 10.1016/j.xcrm.2021.100398
MINTER MR ET AL., SCI REP, vol. 6, 21 July 2016 (2016-07-21), pages 30028
HARACH T. ET AL., SCI REP, vol. 7, 8 February 2017 (2017-02-08), pages 41802
SAJI N. ET AL., SCI REP, vol. 9, no. 1, 30 January 2019 (2019-01-30), pages 1008
HAO Z. ET AL., PSYCHONEUROENDOCRINOLOGY, vol. 104, June 2019 (2019-06-01), pages 132 - 142
BIOINFORMATICS, vol. 31, no. 22, 15 November 2015 (2015-11-15), pages 3691 - 3693
GENOME BIOL., vol. 16, no. 1, 6 August 2015 (2015-08-06), pages 157
HAO ZIKAI; WANG WEI; GUO RONG; LIU HONG: "Faecalibacterium prausnitzii(ATCC 27766) has preventive and therapeutic effects on chronic unpredictable mild stress-induced depression-like and anxiety-like behavior in rats", PSYCHONEUROENDOCRINOLOGY., OXFORD, GB, vol. 104, 1 January 1900 (1900-01-01), GB , pages 132 - 142, XP085669153, ISSN: 0306-4530, DOI: 10.1016/j.psyneuen.2019.02.025
REN TENGZHU, GAO YUYUAN, QIU YIHUI, JIANG SHUOLIN, ZHANG QINGXI, ZHANG JIAHUI, WANG LIMIN, ZHANG YUHU, WANG LIJUAN, NIE KUN: "Gut Microbiota Altered in Mild Cognitive Impairment Compared With Normal Cognition in Sporadic Parkinson's Disease", FRONTIERS IN NEUROLOGY, vol. 11, XP055936044, DOI: 10.3389/fneur.2020.00137
CATTANEO ANNAMARIA; CATTANE NADIA; GALLUZZI SAMANTHA; PROVASI STEFANIA; LOPIZZO NICOLA; FESTARI CRISTINA; FERRARI CLARISSA; GUERRA: "Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly", NEUROBIOLOGY OF AGING, TARRYTOWN, NY, US, vol. 49, 31 August 2016 (2016-08-31), US , pages 60 - 68, XP029828461, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2016.08.019
HARAN JOHN P., BHATTARAI SHAKTI K., FOLEY SAGE E., DUTTA PROTIVA, WARD DOYLE V., BUCCI VANNI, MCCORMICK BETH A.: "Alzheimer’s Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway", MBIO, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 10, no. 3, 25 June 2019 (2019-06-25), US , XP055936063, ISSN: 2161-2129, DOI: 10.1128/mBio.00632-19
LIU PING, WU LI, PENG GUOPING, HAN YUQIU, TANG RUIQI, GE JIANPING, ZHANG LIJIANG, JIA LONGFEI, YUE SIQING, ZHOU KAI, LI LANJUAN, L: "Altered microbiomes distinguish Alzheimer’s disease from amnestic mild cognitive impairment and health in a Chinese cohort", BRAIN, BEHAVIOR AND IMMUNITY., ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 80, 1 August 2019 (2019-08-01), US , pages 633 - 643, XP055936070, ISSN: 0889-1591, DOI: 10.1016/j.bbi.2019.05.008
UEDA ATSUSHI, SHINKAI SHOJI, SHIROMA HIROTSUGU, TANIGUCHI YU, TSUCHIDA SAYAKA, KARIYA TAKAHIRO, KAWAHARA TOMOHIRO, KOBAYASHI YODAI: "Identification of Faecalibacterium prausnitzii strains for gut microbiome-based intervention in Alzheimer’s-type dementia", CELL REPORTS MEDICINE, vol. 2, no. 9, 1 September 2021 (2021-09-01), pages 100398, XP055936073, ISSN: 2666-3791, DOI: 10.1016/j.xcrm.2021.100398
MINTER MR ET AL., SCI REP, vol. 6, 21 July 2016 (2016-07-21), pages 30028
HARACH T. ET AL., SCI REP, vol. 7, 8 February 2017 (2017-02-08), pages 41802
SAJI N. ET AL., SCI REP, vol. 9, no. 1, 30 January 2019 (2019-01-30), pages 1008
HAO Z. ET AL., PSYCHONEUROENDOCRINOLOGY, vol. 104, June 2019 (2019-06-01), pages 132 - 142
BIOINFORMATICS, vol. 31, no. 22, 15 November 2015 (2015-11-15), pages 3691 - 3693
GENOME BIOL., vol. 16, no. 1, 6 August 2015 (2015-08-06), pages 157
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
Download PDF:
Previous Patent: POROUS HOLLOW-FIBER MEMBRANE AND METHOD FOR TESTING INTEGRITY
Next Patent: CONSTRUCTION MACHINE
Next Patent: CONSTRUCTION MACHINE