Title:
COMPOSITION FOR PREVENTING OR TREATING NEUROLOGICAL DISEASES OR PSYCHIATRIC DISEASES COMPRISING VESICLES DERIVED FROM SPHINGOMONAS BACTERIA
Document Type and Number:
WIPO Patent Application WO/2022/124614
Kind Code:
A1
Abstract:
The present invention relates to use for preventing and treating neurological diseases or psychiatric diseases, comprising vesicles derived from Sphingomonas bacteria. The inventors of the present invention confirmed that, when vesicles were isolated from a culture medium of the bacteria and orally administered, the vesicles were delivered into the brain, and, when the vesicles were administered to a brain disease animal model, not only was neurogenesis increased but also the connectivity between neurons was increased, and also confirmed that such therapeutic effects were induced by increasing the expression of neurotrophic factors and receptor genes and simultaneously increasing the expression of Sirt1, Sirt5, and Sirt7 genes that inhibit cellular senescence. In addition, it has been confirmed that vesicles derived from Sphingomonas bacteria inhibit the secretion of inflammatory mediators from inflammatory cells caused by neurological diseases or pathogenic factors. Thus, the vesicles derived from Sphingomonas bacteria according to the present invention improve symptoms caused by brain damage, such as memory ability and spatial perception ability, when administered to a brain disease mouse model, and therefore, are expected to be effectively used in a composition for preventing, ameliorating or treating neurological diseases or psychiatric diseases.
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Inventors:
KIM YOON-KEUN (KR)
Application Number:
PCT/KR2021/016743
Publication Date:
June 16, 2022
Filing Date:
November 16, 2021
Export Citation:
Assignee:
MD HEALTHCARE INC (KR)
International Classes:
A61K35/74; A23L33/135; A61K9/00; A61P25/28
Foreign References:
| KR20200070991A | 2020-06-18 | |||
| KR20180019474A | 2018-02-26 | |||
| US20200254028A1 | 2020-08-13 | |||
| KR20160032722A | 2016-03-24 | |||
| US20200330531A1 | 2020-10-22 | |||
| KR20200170221A | ||||
| KR20210156952A | 2021-12-28 |
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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