Title:
COMPOSITION FOR PREVENTING OR TREATING PULMONARY DISEASES COMPRISING HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 1
Document Type and Number:
WIPO Patent Application WO/2021/158000
Kind Code:
A1
Abstract:
Provided are a recombinant hyaluronan and proteoglycan link protein 1 (HAPLN1), and a composition for preventing or treating pulmonary diseases, the composition comprising at least one selected from the group consisting of HAPLN1 (hyaluronan and proteoglycan link protein 1) protein, a gene coding for the HAPLN 1 protein, and an effective agent for promoting the expression or activating the functions of HAPLN 1 protein or gene as an active ingredient. The recombinant HAPLN 1 according to the present disclosure may have superior effects of improving alveolar damage caused by aging or elastin reduction, and thus may effectively prevent or treat pulmonary diseases, such as chronic bronchitis, asthma, emphysema, and chronic obstructive pulmonary disease.
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Inventors:
KIM DAE KYONG (KR)
PIAO YONG WEI (KR)
JANG JI MIN (KR)
ZHOU DAN (KR)
YUN SO YOON (KR)
PARK BO KYUNG (KR)
PIAO YONG WEI (KR)
JANG JI MIN (KR)
ZHOU DAN (KR)
YUN SO YOON (KR)
PARK BO KYUNG (KR)
Application Number:
PCT/KR2021/001374
Publication Date:
August 12, 2021
Filing Date:
February 02, 2021
Export Citation:
Assignee:
HAPLNSCIENCE INC (KR)
International Classes:
C12N15/63; A23L33/17; A61K38/17; A61P11/00; C07K14/47
Foreign References:
| KR20150053753A | 2015-05-18 | |||
| US20150157565A1 | 2015-06-11 |
Other References:
ECKER BRETT L., KAUR AMANPREET, DOUGLASS STEPHEN M., WEBSTER MARIE R., ALMEIDA FILIPE V., MARINO GLORIA E., SINNAMON ANDREW J., NE: "Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis", CANCER DISCOVERY, vol. 9, no. 1, 1 January 2019 (2019-01-01), pages 82 - 95, XP055803591, ISSN: 2159-8274, DOI: 10.1158/2159-8290.CD-18-0168
ZANINI ANDREA; CHETTA ALFREDO; IMPERATORI ANDREA S; SPANEVELLO ANTONIO; OLIVIERI DARIO: "The role of the bronchial microvasculature in the airway remodelling in asthma and COPD", RESPIRATORY RESEARCH, vol. 11, no. 1, 132, 29 September 2010 (2010-09-29), pages 1 - 11, XP021071351, ISSN: 1465-9921, DOI: 10.1186/1465-9921-11-132
DATABASE Protein 27 June 2021 (2021-06-27), ANONYMOUS: "hyaluronan and proteoglycan link protein 1 precursor [Homo sapiens]", XP055833208, retrieved from NCBI Database accession no. NP_001875
SUKI ET AL., METHODS MOL. BIOL., vol. 1639, 2017, pages 67 - 75
WRIGHT ET AL., AM J PHYSIOL LUNG MOL PHYSIOL, vol. 295, 2008
CANTOR ET AL., EXPERIMENTAL LUNG RESEARCH, vol. 31, 2005, pages 417 - 430
See also references of EP 3887525A4
ZANINI ANDREA; CHETTA ALFREDO; IMPERATORI ANDREA S; SPANEVELLO ANTONIO; OLIVIERI DARIO: "The role of the bronchial microvasculature in the airway remodelling in asthma and COPD", RESPIRATORY RESEARCH, vol. 11, no. 1, 132, 29 September 2010 (2010-09-29), pages 1 - 11, XP021071351, ISSN: 1465-9921, DOI: 10.1186/1465-9921-11-132
DATABASE Protein 27 June 2021 (2021-06-27), ANONYMOUS: "hyaluronan and proteoglycan link protein 1 precursor [Homo sapiens]", XP055833208, retrieved from NCBI Database accession no. NP_001875
SUKI ET AL., METHODS MOL. BIOL., vol. 1639, 2017, pages 67 - 75
WRIGHT ET AL., AM J PHYSIOL LUNG MOL PHYSIOL, vol. 295, 2008
CANTOR ET AL., EXPERIMENTAL LUNG RESEARCH, vol. 31, 2005, pages 417 - 430
See also references of EP 3887525A4
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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