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Patent Searching and Data


Title:
COMPOSITION FOR PREVENTING OR TREATING SALIVARY GLAND DISESAES USING CELL-DERIVED VESICLE
Document Type and Number:
WIPO Patent Application WO/2021/045567
Kind Code:
A1
Abstract:
The present invention relates to a salivary gland therapeutic agent using the effects of a cell-derived vesicle of enhancing the proliferation capacity of salivary gland cells, promoting an amylase activity, and enhancing transepithelial resistance. A pharmaceutical composition comprising the cell-derived vesicle according to the present invention has the effects of enhancing the proliferation capacity of salivary gland tissue cells damaged by radiation, promoting amylase activity, increasing transepithelial resistance, enhancing the expression of Aquaporin 5, and increasing the amount of saliva secretion. Therefore, the pharmaceutical composition comprising the cell-derived vesicle of the present invention can be used for preventing and treating salivary gland diseases, and thus can be widely used in the pharmaceutical industry and health functional food field.

Inventors:
BAE SHIN GYU (KR)
OH SEUNG WOOK (KR)
KIM SE HEE (KR)
HAN SUNG HOON (KR)
CHOI JEONG SEOK (KR)
KIM JEONG MI (KR)
Application Number:
PCT/KR2020/011957
Publication Date:
March 11, 2021
Filing Date:
September 04, 2020
Export Citation:
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Assignee:
MDIMUNE INC (KR)
INHA IND PARTNERSHIP INST (KR)
International Classes:
A61K35/38; A23L33/10; A61K35/28; A61P5/00; A61P43/00
Domestic Patent References:
WO2019040896A12019-02-28
Foreign References:
KR20180003322A2018-01-09
KR20140118524A2014-10-08
KR20190093141A2019-08-08
Other References:
BO HAI, TAEKO SHIGEMOTO-KURODA, QINGGUO ZHAO, RYANG HWA LEE, FEI LIU: "Inhibitory Effects of iPSC-MSCs and Their Extracellular Vesicles on the Onset of Sialadenitis in a Mouse Model of Sjögren’s Syndrome", STEM CELLS INTERNATIONAL, vol. 2018, 2092315, 15 March 2018 (2018-03-15), Hindawi Publishing Corporation, US, pages 1 - 10, XP055716853, ISSN: 1687-966X, DOI: 10.1155/2018/2092315
Attorney, Agent or Firm:
KIM, Soon Woong (KR)
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