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Patent Searching and Data


Title:
COMPOSITION FOR PREVENTING OR TREATING SENSORINEURAL HEARING LOSS
Document Type and Number:
WIPO Patent Application WO/2023/190707
Kind Code:
A1
Abstract:
[Problem] To clarify the mechanism of the medial olivocochlear (MOC) feedback system and provide a composition for preventing or treating auditory disorders in which MOC neurons participate. To provide a method for screening a compound for preventing or treating auditory disorders in which MOC neurons participate. [Solution] A composition for preventing or treating sensorineural hearing loss that contains a serotonin 3 receptor agonist. Sensorineural hearing loss includes acoustic trauma hearing loss, age-related hearing loss, etc. Also provided is a composition for activating MOC neurons that contains a serotonin 3 receptor agonist. The serotonin 3 receptor agonist activates MOC neurons and thus enables the prevention and treatment of sensorineural hearing loss. Also provided are: a method for screening a compound for preventing or treating sensorineural hearing loss, said method including a step for measuring serotonin 3 receptor agonist activity; and a method for screening a compound activating MOC neurons.

Inventors:
SHIMADA SHOICHI (JP)
KONDO MAKOTO (JP)
INOHARA HIDENORI (JP)
OHATA KAZUYA (JP)
Application Number:
PCT/JP2023/012857
Publication Date:
October 05, 2023
Filing Date:
March 29, 2023
Export Citation:
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Assignee:
UNIV OSAKA (JP)
International Classes:
A61K31/4545; A23L2/52; A23L33/10; A61K45/00; A61P27/16; A61P43/00
Foreign References:
US10434097B12019-10-08
JP2015107995A2015-06-11
Other References:
OHATA KAZUYA, KONDO MAKOTO, OZONO YOSHIYUKI, HANADA YUKIKO, SATO TAKASHI, INOHARA HIDENORI, SHIMADA SHOICHI: "Cochlear protection against noise exposure requires serotonin type 3A receptor via the medial olivocochlear system", THE FASEB JOURNAL, FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY, US, vol. 35, no. 5, 1 May 2021 (2021-05-01), US, XP093096347, ISSN: 0892-6638, DOI: 10.1096/fj.202002383R
OHATA KAZUYA: "Cochlear protection against noise exposure requires serotonin type 3A receptor via the medial olivocochlear system", OSAKA UNIVERSITY KNOWLEDGE ARCHIVE, 17 December 2021 (2021-12-17), XP093096355, Retrieved from the Internet
OHATA, KAZUYA ET AL.: "O38-1 Cochlear protection against noise exposure requires serotonin type 3A receptor via the medial olivocochlear system", THE 31ST ANNUAL MEETING OF THE JAPAN OTOLOGICAL SOCIETY; TOKYO, JAPAN; OCTOBER 13-16, 2021, vol. 31, 13 October 2021 (2021-10-13), pages 356, XP009549840
CRUZ OSWALDO LAERICO M., KASSE CRISTIANE A, SANCHEZ MAURA, BARBOSA FLAVIO, BARROS FLAVIA A: "Serotonin Reuptake Inhibitors in Auditory Processing Disorders in Elderly Patients: Preliminary Results", THE LARYNGOSCOPE, vol. 114, 1 September 2004 (2004-09-01), pages 1656 - 1659, XP093096398
KANG HSIAO-HSIEN; WANG CHIH-HUNG; CHEN HSIN-CHIEN; LI I-HSUN; CHENG CHENG-YI; LIU REN-SHYAN; HUANG WEN-SHENG; SHIUE CHYNG-YANN; MA: "Investigating the effects of noise-induced hearing loss on serotonin transporters in rat brain using 4-[18F]-ADAM/small animal PET", NEUROIMAGE, ELSEVIER, AMSTERDAM, NL, vol. 75, 2 July 2012 (2012-07-02), AMSTERDAM, NL , pages 262 - 269, XP028579875, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2012.06.049
KOYAMA YOSHIHISA, KONDO MAKOTO, SHIMADA SHOICHI: "Building a 5-HT3A Receptor Expression Map in the Mouse Brain", SCIENTIFIC REPORTS, vol. 7, no. 1, XP093096401, DOI: 10.1038/srep42884
Attorney, Agent or Firm:
SHOJI Takashi et al. (JP)
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