Title:
COMPOSITION FOR PREVENTING OR TREATING STRESS-RELATED DISEASES INCLUDING METHYL BENZOATE AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2021/091356
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition, a functional food composition, and a cosmetic composition which include methyl benzoate or a derivative thereof as an active ingredient, and are for preventing or treating stress-related diseases. A composition according to the present invention significantly improves behavioral indicators of individuals exposed to stressful environments, significantly reduces blood cortisol concentration, and significantly suppresses cortisol concentration and stress-related gene expression in skin fibroblasts, and can thus be applied to neurological diseases and skin diseases caused by stress, as well as to various stress-related diseases accompanied by increased cortisol secretion. The present invention uses, as an active ingredient, a naturally-derived compound that is already being consumed as a food additive, and thus has few side effects even when administered for a long time. Thus, the present invention can be effectively used as an effective therapeutic composition for various stress-related diseases, most of which are chronic diseases.
Inventors:
PARK TAESUN (KR)
Application Number:
PCT/KR2020/015652
Publication Date:
May 14, 2021
Filing Date:
November 09, 2020
Export Citation:
Assignee:
UNIV YONSEI IACF (KR)
International Classes:
A61K31/235; A23L33/10; A61K8/37; A61P9/00; A61P17/00; A61P25/00; A61P31/00; A61P43/00; A61Q19/00
Foreign References:
| KR101937321B1 | 2019-01-10 | |||
| KR20190101264A | 2019-08-30 | |||
| KR20190105392A | 2019-09-17 | |||
| US20190060263A1 | 2019-02-28 |
Other References:
KHOSHNOUD MOHAMMAD JAVAD, SIAVASHPOUR ASMA, BAKHSHIZADEH MOJGAN, RASHEDINIA MARZIEH: "Effects of sodium benzoate, a commonly used food preservative, on learning, memory, and oxidative stress in brain of mice", JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, WILEY, US, vol. 32, no. 2, 1 February 2018 (2018-02-01), US, pages e22022, XP055810316, ISSN: 1095-6670, DOI: 10.1002/jbt.22022
Attorney, Agent or Firm:
CHUNG HYUN PATENT & LAW FIRM (KR)
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