Title:
COMPOSITION FOR PREVENTING OR TREATING TNF-RELATED DISEASES, CONTAINING NOVEL DERIVATIVE AS ACTIVE INGREDIENT, AND METHOD FOR INHIBITING TNF ACTIVITY BY USING SAME
Document Type and Number:
WIPO Patent Application WO/2019/078452
Kind Code:
A1
Abstract:
The present invention relates to: a 4-benzopyranone derivative and a pharmaceutically acceptable salt, solvate, racemate or stereoisomer thereof; a composition for preventing, alleviating or treating TNF-related diseases, containing the same as an active ingredient; and a method for treating TNF-related diseases, a reagent composition for inhibiting TNF and a method for inhibiting TNF, all of which use the same. The compositions can be orally administered so as not to cause injection side effects, do not cause immunological tolerance, and can effectively inhibit TNF activity by being directly bound to TNF while facilitating co-administering with a conventional oral preparation and dosage control.
Inventors:
HEO TAE-HWE (KR)
SHIN KYE JUNG (KR)
PARK YEON-HWA (KR)
SHIN KYE JUNG (KR)
PARK YEON-HWA (KR)
Application Number:
PCT/KR2018/007922
Publication Date:
April 25, 2019
Filing Date:
July 12, 2018
Export Citation:
Assignee:
CATHOLIC UNIV KOREA IND ACADEMIC COOPERATION FOUNDATION (KR)
International Classes:
C07D311/22; A23L33/10; A61K31/353; A61K45/06
Foreign References:
| KR20080013162A | 2008-02-13 | |||
| US4886806A | 1989-12-12 |
Other References:
LIN, J.-P. ET AL.: "Transition Metal-free One-pot Synthesis of 2-substituted 3-carboxy-4-quinolone and Chromone Derivatives", CHEMICAL COMMUNICATIONS, vol. 49, no. 46, 2013, pages 5313 - 5315, XP055597047
DONG, Q. ET AL.: "Efficient Synthesis of Functionalized Chromones via a Two-base Mediated Formal [3+3] Cycloaddition", TETRAHEDRON LETTERS, vol. 57, no. 19, 2016, pages 2116 - 2120, XP029512947, DOI: doi:10.1016/j.tetlet.2016.04.010
YOSHIDA, M. ET AL.: "A Concise Total Synthesis of Biologically Active Frutinones via Tributylphosphine-catalyzed Tandem Acyl Transfer-cyclization", TETRAHEDRON, vol. 70, no. 21, May 2014 (2014-05-01), pages 3452 - 3458, XP055597058
COSTA, A. M. B. S. R. C. S. ET AL.: "Two Exceptional Lithiations in the Chromone Series", JOURNAL OF THE CHEMICAL SOCIETY CHEMICAL COMMUNICATIONS, vol. 19, 1 January 1983 (1983-01-01), pages 1098 - 1099, XP009151482
COSTA, A. M. B. S. R. C. S. ET AL.: "Lithiation in Flavones, Chromones, Coumarins, and Benzofuran Derivatives", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS, vol. 1, 1985, pages 799 - 808, XP008063811, DOI: doi:10.1039/p19850000799
WANG, P. ET AL.: "Metal-free Catalytic Cascade to Chromones: Direct Coupling of Salicylaldehydes and Activated Alkynes Triggered by Aryloxyl Radical", RSC ADVANCES, vol. 5, no. 129, 2015, pages 106350 - 106354, XP055597040
SUN, P. ET AL.: "Controllable Rh(iii)-catalyzed Annulation between Salicylaldehydes and Diazo Compounds: Divergent Synthesis of Chromones and Benzofurans", ORGANIC LETTERS, vol. 18, no. 24, 2016, pages 6464 - 6467, XP055597043
HE ET AL., SCIENCE, vol. 310, no. 5750, 2005, pages 1022 - 1025
See also references of EP 3699174A4
DONG, Q. ET AL.: "Efficient Synthesis of Functionalized Chromones via a Two-base Mediated Formal [3+3] Cycloaddition", TETRAHEDRON LETTERS, vol. 57, no. 19, 2016, pages 2116 - 2120, XP029512947, DOI: doi:10.1016/j.tetlet.2016.04.010
YOSHIDA, M. ET AL.: "A Concise Total Synthesis of Biologically Active Frutinones via Tributylphosphine-catalyzed Tandem Acyl Transfer-cyclization", TETRAHEDRON, vol. 70, no. 21, May 2014 (2014-05-01), pages 3452 - 3458, XP055597058
COSTA, A. M. B. S. R. C. S. ET AL.: "Two Exceptional Lithiations in the Chromone Series", JOURNAL OF THE CHEMICAL SOCIETY CHEMICAL COMMUNICATIONS, vol. 19, 1 January 1983 (1983-01-01), pages 1098 - 1099, XP009151482
COSTA, A. M. B. S. R. C. S. ET AL.: "Lithiation in Flavones, Chromones, Coumarins, and Benzofuran Derivatives", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS, vol. 1, 1985, pages 799 - 808, XP008063811, DOI: doi:10.1039/p19850000799
WANG, P. ET AL.: "Metal-free Catalytic Cascade to Chromones: Direct Coupling of Salicylaldehydes and Activated Alkynes Triggered by Aryloxyl Radical", RSC ADVANCES, vol. 5, no. 129, 2015, pages 106350 - 106354, XP055597040
SUN, P. ET AL.: "Controllable Rh(iii)-catalyzed Annulation between Salicylaldehydes and Diazo Compounds: Divergent Synthesis of Chromones and Benzofurans", ORGANIC LETTERS, vol. 18, no. 24, 2016, pages 6464 - 6467, XP055597043
HE ET AL., SCIENCE, vol. 310, no. 5750, 2005, pages 1022 - 1025
See also references of EP 3699174A4
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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