Title:
COMPOSITION FOR PREVENTION OR TREATMENT OF CANCER COMPRISING COMPOUND REPRESENTED BY FORMULA 1
Document Type and Number:
WIPO Patent Application WO/2020/040600
Kind Code:
A1
Abstract:
The present invention relates to a novel use of a compound represented by formula 1 which can be utilized for prevention or treatment of cancer. More specifically, the compound of the present invention can inhibit metastasis and invasion of cancer cells by inhibiting the levels of MMP-9 and IL-8 or reducing the activity of PKCα and JNK.
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Inventors:
YOON DO YOUNG (KR)
KIM SOO JIN (KR)
OH SEI RYANG (KR)
RYU HYUNG WON (KR)
KIM DOO YOUNG (KR)
AHN KYUNG SEOP (KR)
KIM SOO JIN (KR)
OH SEI RYANG (KR)
RYU HYUNG WON (KR)
KIM DOO YOUNG (KR)
AHN KYUNG SEOP (KR)
Application Number:
PCT/KR2019/010774
Publication Date:
February 27, 2020
Filing Date:
August 23, 2019
Export Citation:
Assignee:
UNIV KONKUK IND COOP CORP (KR)
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)
International Classes:
A61K31/7048; A23L33/105; A61K36/899; A61P35/04
Domestic Patent References:
| WO2016178713A1 | 2016-11-10 |
Other References:
KIM, S. -J. ET AL.: "7-Methoxy-luteolin-8-C-beta-6-deoxy-xylo-pyranos-3-guloside exactly (mLU8C-PU) isolated from Arthraxon hispidus inhibits migratory and invasive responses mediated via downregulation of MMP-9 and IL-8 expression in MCF-7 breast cancer cells", ENVIRONMENTAL TOXICOLOGY, vol. 33, no. 11, 22 August 2018 (2018-08-22), pages 1143 - 1152, XP055687887
CZEMPLIK, M. ET AL.: "Flavonoid C-glucosides Derived from Flax Straw Extracts Reduce Human Breast Cancer Cell Growth In vitro and Induce Apoptosis", FRONTIERS IN PHARMACOLOGY, vol. 7, 2016, pages 1 - 13, XP055687883
GUO, T. -T. ET AL.: "Bioactive spirans and other constituents from the leaves of Cannabis sativa f. sativa", JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, vol. 19, no. 8, 2016, pages 793 - 802, XP055687880
PARK, S. -B. ET AL.: "Luteolin 8-C-beta-fucopyranosicle inhibits invasion and suppresses TPA-induced MMP-9 and IL-8 via ERK/ AP-1 and ERK/NF-kappaB signaling in MCF-7 breast cancer cells", BIOCHIMIE, vol. 95, 2013, pages 2082 - 2090, XP028731037
CZEMPLIK, M. ET AL.: "Flavonoid C-glucosides Derived from Flax Straw Extracts Reduce Human Breast Cancer Cell Growth In vitro and Induce Apoptosis", FRONTIERS IN PHARMACOLOGY, vol. 7, 2016, pages 1 - 13, XP055687883
GUO, T. -T. ET AL.: "Bioactive spirans and other constituents from the leaves of Cannabis sativa f. sativa", JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, vol. 19, no. 8, 2016, pages 793 - 802, XP055687880
PARK, S. -B. ET AL.: "Luteolin 8-C-beta-fucopyranosicle inhibits invasion and suppresses TPA-induced MMP-9 and IL-8 via ERK/ AP-1 and ERK/NF-kappaB signaling in MCF-7 breast cancer cells", BIOCHIMIE, vol. 95, 2013, pages 2082 - 2090, XP028731037
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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