Title:
COMPOSITION TARGETED TO ADENOSINE A2A RECEPTOR
Document Type and Number:
WIPO Patent Application WO/2021/084791
Kind Code:
A1
Abstract:
The purpose of the invention is to identify a new receptor participating in the differentiation of helper T cells and to develop a drug targeted thereto. It has been discovered that an adenosine A2A receptor participates in control of the differentiation and activation of Th17 cells. It has also been discovered that antagonists for the receptor are effective as drugs for diseases caused by Th17 cell overreaction.
Inventors:
MATSUSHITA SHO (JP)
KAWANO MASAAKI (JP)
TAKAGI RIE (JP)
TOKANO MIEKO (JP)
KAWANO MASAAKI (JP)
TAKAGI RIE (JP)
TOKANO MIEKO (JP)
Application Number:
PCT/JP2020/024876
Publication Date:
May 06, 2021
Filing Date:
June 24, 2020
Export Citation:
Assignee:
IMMNO INC (JP)
UNIV SAITAMA MEDICAL (JP)
UNIV SAITAMA MEDICAL (JP)
International Classes:
A61K45/00; A61K31/522; A61P17/06; A61P43/00; C07K14/705; C12N5/0783; C12Q1/06
Foreign References:
| JP2005513043A | 2005-05-12 | |||
| JP2006160628A | 2006-06-22 |
Other References:
LIANG DONGCHUN, ZUO AIJUN, SHAO HUI, CHEN MINGJIAZI, KAPLAN HENRY J., SUN DEMING: "Anti-Inflammatory or Proinflammatory Effect of an Adenosine Receptor Agonist on the Thl7 Autoimmune Response Is Inflammatory Environment-Dependent", THE JOURNAL OF IMMUNOLOGY, vol. 193, no. 11, 1 December 2014 (2014-12-01), pages 5498 - 5505, XP055820880
WANG LINLIN, WAN HUANYING, TANG WEI, NI YINGMENG, HOU XIAOXIA, PAN LINA, SONG YUANLIN, SHI GUOCHAO: "Critical roles of adenosine A2A receptor in regulating the balance of Treg/Thl7 cells in allergic asthma", CLINICAL RESPIRATORY JOURNAL, vol. 12, no. 1, 2018, pages 149 - 157, XP055820882
ANSARI, MUSHTAQ A. ET AL.: "Adenosine A2A receptor modulates neuroimmune function through Thl7/retinoid-related orphan receptor gamma t(RORyt) signaling in a BTBR T+ Itpr3tf/J mouse model of autism", CELLULAR SIGNALLING, vol. 36, 2017, pages 14 - 24, XP085043679, DOI: 10.1016/j.cellsig.2017.04.014
ALCHERA, ELISA ET AL.: "Adenosine A2a receptor stimulation blocks development of nonalcoholic steatohepatitis in mice by multilevel inhibition of signals that cause immunolipotoxicity", TRANSLATIONAL RESEARCH, vol. 182, 2017, pages 75 - 87, XP029947175, DOI: 10.1016/j.trsl.2016.11.009
WANG LINLIN, WAN HUANYING, TANG WEI, NI YINGMENG, HOU XIAOXIA, PAN LINA, SONG YUANLIN, SHI GUOCHAO: "Critical roles of adenosine A2A receptor in regulating the balance of Treg/Thl7 cells in allergic asthma", CLINICAL RESPIRATORY JOURNAL, vol. 12, no. 1, 2018, pages 149 - 157, XP055820882
ANSARI, MUSHTAQ A. ET AL.: "Adenosine A2A receptor modulates neuroimmune function through Thl7/retinoid-related orphan receptor gamma t(RORyt) signaling in a BTBR T+ Itpr3tf/J mouse model of autism", CELLULAR SIGNALLING, vol. 36, 2017, pages 14 - 24, XP085043679, DOI: 10.1016/j.cellsig.2017.04.014
ALCHERA, ELISA ET AL.: "Adenosine A2a receptor stimulation blocks development of nonalcoholic steatohepatitis in mice by multilevel inhibition of signals that cause immunolipotoxicity", TRANSLATIONAL RESEARCH, vol. 182, 2017, pages 75 - 87, XP029947175, DOI: 10.1016/j.trsl.2016.11.009
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
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