Title:
COMPOSITION FOR TGR5 ACTIVATION
Document Type and Number:
WIPO Patent Application WO/2021/085291
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: a composition for TGR5 activation, said composition comprising, as an active ingredient, a substance that has an effect of activating TGR5 and shows a high selectivity for TGR5; and a method for activating TGR5 using a substance that shows a high selectivity for TGR5. The present invention pertains to a composition for TGR5 activation that comprises, as an active ingredient, at least one kind of soyasapogenol, etc.
Inventors:
KASAJIMA NAOKI (JP)
FUNAKI AYUTA (JP)
FUNAKI AYUTA (JP)
Application Number:
PCT/JP2020/039684
Publication Date:
May 06, 2021
Filing Date:
October 22, 2020
Export Citation:
Assignee:
SUNTORY HOLDINGS LTD (JP)
International Classes:
A23L2/52; A61K31/045; A23L33/105; A61K8/63; A61K8/9789; A61K9/08; A61K9/16; A61K9/20; A61K36/48; A61P1/10; A61P1/14; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P21/06; A61P43/00; C07J63/00
Foreign References:
| JP2016027012A | 2016-02-18 | |||
| JP2016027012A | 2016-02-18 |
Other References:
KAZUKO IWAMOTOA, SHUICHI KAMO, YUICHI TAKADA, AYANA IEDA, TAKATOSHI YAMASHITA, TOSHIRO SATO, NOBUHIRO ZAIMA, TATSUYA MORIYAMA: "Soyasapogenols reduce cellular triglyceride levels in 3T3-L1 mouse adipocyte cells by accelerating triglyceride lipolysis", BIOCHEMISTRY AND BIOPHYSICS REPORTS, vol. 16, 2018, pages 44 - 49, XP055822392, ISSN: 2405-5808
KAMO SHUICHI, TAKADA YUICHI, YAMASHITA TAKATOSHI, SATO TOSHIRO, YANO ERIKA, ZAIMA NOBUHIRO, MORIYAMA TATSUYA: "Group B Soyasaponin Aglycone Suppresses Body Weight Gain and Fat Levels in High Fat-Fed Mice", JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, vol. 64, 2018, pages 222 - 228, XP055822394, ISSN: 1881-7742
RUPASINGHE H. P. VASANTHA, JACKSON CHUNG-JA C., POYSA VAINO, DI BERARDO CHRISTINA, BEWLEY J. DEREK, JENKINSON JONATHAN: "Soyasapogenol A and B Distribution in Soybean (Glycine max L. Merr.) in Relation to Seed Physiology, Genetic Variability, and Growing Location", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 51, no. 20, 2003, pages 5888 - 5894, XP055822397, ISSN: 1520-5118
SASAKI ET AL., J. BIOL. CHEM., vol. 293, no. 26, 2018, pages 10322 - 10332
ALEMI ET AL., GASTROENTEROLOGY, vol. 144, no. 1, January 2013 (2013-01-01), pages 145 - 154
IRACHETA-VELLVE A ET AL., HEPATOL COMMUN, vol. 2, no. 11, 15 October 2018 (2018-10-15), pages 1379 - 1391
KAMO SHUICHI, TAKADA YUICHI, YAMASHITA TAKATOSHI, SATO TOSHIRO, YANO ERIKA, ZAIMA NOBUHIRO, MORIYAMA TATSUYA: "Group B Soyasaponin Aglycone Suppresses Body Weight Gain and Fat Levels in High Fat-Fed Mice", JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, vol. 64, 2018, pages 222 - 228, XP055822394, ISSN: 1881-7742
RUPASINGHE H. P. VASANTHA, JACKSON CHUNG-JA C., POYSA VAINO, DI BERARDO CHRISTINA, BEWLEY J. DEREK, JENKINSON JONATHAN: "Soyasapogenol A and B Distribution in Soybean (Glycine max L. Merr.) in Relation to Seed Physiology, Genetic Variability, and Growing Location", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 51, no. 20, 2003, pages 5888 - 5894, XP055822397, ISSN: 1520-5118
SASAKI ET AL., J. BIOL. CHEM., vol. 293, no. 26, 2018, pages 10322 - 10332
ALEMI ET AL., GASTROENTEROLOGY, vol. 144, no. 1, January 2013 (2013-01-01), pages 145 - 154
IRACHETA-VELLVE A ET AL., HEPATOL COMMUN, vol. 2, no. 11, 15 October 2018 (2018-10-15), pages 1379 - 1391
Attorney, Agent or Firm:
YASUTOMI & ASSOCIATES (JP)
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