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Patent Searching and Data


Title:
COMPOSITIONS FOR CHELATING METALS AT LOW TEMPERATURES
Document Type and Number:
WIPO Patent Application WO/2019/240884
Kind Code:
A3
Abstract:
A method of performing a chelating reaction comprising contacting a divalent metal with a compound of Formula (I): or a salt thereof wherein: each of R1-R4 is independently selected from the group consisting of CH2COORa and CH2C(=O)NHRa; each of R5-R12 is independently selected from the group consisting of H and -L-X; each Ra is independently selected from the group consisting of H and -L-X; each L is independently selected from the group consisting of absent and a linking group; and each X is a biological agent; and wherein the contacting occurs at a temperature below about 40°C to form a chelated composition.

Inventors:
SCHULTZ MICHAEL (US)
PIGGE CHRISTOPHER (US)
LI MENGSHI (US)
GABR MOUSTAFA (US)
SAGASTUME EDWIN (US)
Application Number:
PCT/US2019/029102
Publication Date:
July 23, 2020
Filing Date:
April 25, 2019
Export Citation:
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Assignee:
UNIV IOWA RES FOUND (US)
SCHULTZ MICHAEL K (US)
PIGGE CHRISTOPHER (US)
LI MENGSHI (US)
GABR MOUSTAFA (US)
SAGASTUME EDWIN (US)
International Classes:
A61K49/10; C07D257/02
Domestic Patent References:
WO2017165473A12017-09-28
Foreign References:
US20170266304A12017-09-21
US20080193384A12008-08-14
US5435990A1995-07-25
US9579404B22017-02-28
Other References:
CORBIN ET AL.: "Screening of ligands for redox-active europium using magnetic resonance ''imaging", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 26, 2018, pages 5274 - 5279, XP085529199, DOI: 10.1016/j.bmc.2018.04.001
Attorney, Agent or Firm:
VIKSNINS, Ann, S. et al. (US)
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