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Title:
COMPOSITIONS CONTAINING HYPOGLYCEMICALLY ACTIVE STILBENOIDS
Document Type and Number:
WIPO Patent Application WO2002014252
Kind Code:
A3
Abstract:
The use of isolated or purified stilbenoid compounds including longistyline A-2-carboxylic acid as hypoglycemic agents or to lower serum glucose levels is described. The invention also relates to the use of such stibenoid compounds in combination with other hypoglycemic agents.

Inventors:
HOPP DAVID CRAIG
INMAN WAYNE D
Application Number:
PCT/US2001/025382
Publication Date:
September 12, 2002
Filing Date:
August 15, 2001
Export Citation:
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Assignee:
INSMED INC (US)
International Classes:
A61K31/05; A61K31/085; A61K31/192; (IPC1-7): A61K31/192; A61K31/05; A61K31/085; A61P3/10
Domestic Patent References:
WO2000026167A12000-05-11
WO1999056737A11999-11-11
WO2001042231A22001-06-14
WO2000069430A12000-11-23
WO2002013811A22002-02-21
WO2002013809A22002-02-21
WO2002013806A22002-02-21
Foreign References:
Other References:
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; COTIAS, CLAUDIO TENORIO ET AL: "Longistyline C, antibiotic isolated from Lonchocarpus longistyllus. Preliminary results of its pharmacological properties", XP002195757, retrieved from STN Database accession no. 93:37284
GONCALVES DE LIMA O.: "Antimicrobial substances from higher plants XLVI. Initial observations on biological effects of extract from the stembark and rootbark of Lonchocarpus Violaceus (= L. Longistyllus), a Mexican Mayan, Guatemalan and Honduran plant", REV. INST. ANTIBIOT. UNIV. FED. PERNAMBUCO RECIFE, vol. 15, 1975, pages 3 - 15, XP008001793
ASAKAWA Y ET AL: "PRENYL BIBENZYLS FROM THE LIVERWORTS RADULA-PERROTTETII AND RADULA-COMPLANATA", PHYTOCHEMISTRY (OXFORD), vol. 30, no. 1, 1991, pages 235 - 252, XP008001857, ISSN: 0031-9422
ASAKAWA, YOSHINORI ET AL: "Chemosystematics of bryophytes. Part 39. Prenyl bibenzyls from the liverwort Radula kojana", PHYTOCHEMISTRY (1991), 30(1), 219-34, XP008001856
SHIMIZU KUNIYOSHI ET AL: "The inhibitory components from Artocarpus incisus on melanin biosynthesis.", PLANTA MEDICA, vol. 64, no. 5, June 1998 (1998-06-01), pages 408 - 412, XP008001756, ISSN: 0032-0943
MITSCHER L A ET AL: "ANTI MICROBIAL AGENTS FROM HIGHER PLANTS PRENYLATED FLAVONOIDS AND OTHER PHENOLS FROM GLYCYRRHIZA-LEPIDOTA", PHYTOCHEMISTRY (OXFORD), vol. 22, no. 2, 1983, pages 573 - 576, XP008001858, ISSN: 0031-9422
MITSCHER, LESTER A. ET AL: "Amorfrutin A and B, bibenzyl antimicrobial agents from Amorpha fruticosa", PHYTOCHEMISTRY (1981), 20(4), 781-5, XP008001855
BOONLAKSIRI CHOOSAK ET AL: "An antimalarial stilbene from Artocarpus integer.", PHYTOCHEMISTRY (OXFORD), vol. 54, no. 4, June 2000 (2000-06-01), pages 415 - 417, XP002195755, ISSN: 0031-9422
AMALRAJ T ET AL: "Hypoglycemic activity of Cajanus cajan (seeds) in mice.", INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, (1998 OCT) 36 (10) 1032-3., XP008001757
VISWANATHAN, M. ET AL: "Responses to legumes in NIDDM subjects: lower plasma glucose and higher insulin levels", NUTR. REP. INT. (1989), 40(4), 803-12, XP008001760
ESPOSITO AVELLA M ET AL: "[Evaluation of traditional medicine: effects of Cajanus cajan L. and of Cassia fistula L. on carbohydrate metabolism in mice]. Evaluacion de la medicina tradicional: efectos de Cajanus cajan L. (Guandu) y de Cassia fistula L. (canafistula) en el metabolismo de los carbohidratos en el raton.", REVISTA MEDICA DE PANAMA, (1991 JAN) 16 (1) 39-45., XP008001759
MANICKAM, M. ET AL: "Antihyperglycemic Activity of Phenolics from Pterocarpus marsupium", J. NAT. PROD. (1997), 60(6), 609-610, XP001066243
DATABASE NAPRALERT [online] CHEN D.H., LI H.Y., LIN H.: "Chemical constituents of Cajanus Cajan (L) millisp. leaves", XP002195759, Database accession no. 95:6363
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