Title:
COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING RADIATION-INDUCED BYSTANDER EFFECTS CAUSED BY RADIATION OR RADIOTHERAPY
Document Type and Number:
WIPO Patent Application WO/2019/018451
Kind Code:
A3
Abstract:
The invention provides novel compositions and methods for the treatment of Radiation-Induced Bystander Effects (RIBE), resulting from radiation exposure. In one preferred embodiment the inventions includes novel therapeutic agents, including but not limited to quercetin and quercetin analogs, as well as E64, CA074, CA074Me, that interfere with the activity of Cathepsin B.
Inventors:
XUE DING (US)
PENG YU (CN)
ZHANG MAN (CN)
ZHENG LINGJUN (US)
LIANG QIAN (CN)
LI HANZENG (US)
YU JAU-SONG (TW)
CHEN JENG-TING (TW)
PENG YU (CN)
ZHANG MAN (CN)
ZHENG LINGJUN (US)
LIANG QIAN (CN)
LI HANZENG (US)
YU JAU-SONG (TW)
CHEN JENG-TING (TW)
Application Number:
PCT/US2018/042569
Publication Date:
March 14, 2019
Filing Date:
July 17, 2018
Export Citation:
Assignee:
UNIV COLORADO REGENTS (US)
International Classes:
A61K38/17
Foreign References:
| US20120020902A1 | 2012-01-26 | |||
| US20100257636A1 | 2010-10-07 |
Other References:
OZYURT ET AL.: "Quercetin protects radiation-induced DNA damage and apoptosis in kidney and bladder tissues of rats", FREE RADICAL RESEARCH, vol. 48, 14 August 2014 (2014-08-14), pages 1247 - 1255, XP055580922
LIN ET AL.: "Combination of quercetin with radiotherapy enhances tumor radiosensitivity in vitro and in vivo", RADIOTHERAPY AND ONCOLOGY, vol. 104, 25 November 2011 (2011-11-25), pages 395 - 400, XP055344438, DOI: doi:10.1016/j.radonc.2011.10.023
ZWICKY ET AL.: "Cathepsin B expression and down-regulation by gene silencing and antisense DNA in human chondrocytes", BIOCHEMICAL JOURNAL, vol. 367, 1 October 2002 (2002-10-01), XP002273726, DOI: doi:10.1042/BJ20020210
GONDI ET AL.: "Cathepsin B as a Cancer Target", EXPERT OPINION ON THERAPEUTIC TARGETS, vol. 17, 8 January 2013 (2013-01-08), pages 281 - 291, XP055387981, DOI: doi:10.1517/14728222.2013.740461
WANG ET AL.: "Quercetin, a flavonoid with anti-inflammatory activity, suppresses the development of abdominal aortic aneurysms in mice", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 690, 19 June 2012 (2012-06-19), pages 133 - 141, XP028934368, DOI: doi:10.1016/j.ejphar.2012.06.018
ALAPATI ET AL.: "uPAR and cathepsin B knockdown inhibits radiation-induced PKC integrated integrin signaling to the cytoskeleton of glioma-initiating cells", INTERNATIONAL JOURNAL OF ONCOLOGY, 24 May 2012 (2012-05-24), pages 599 - 610, XP055580925
PIAO ET AL.: "Hyperoside Protects Cells against Gamma Ray Radiation-Induced Apoptosis in Hamster Lung Fibroblast", NATURAL PRODUCT SCIENCES, vol. 19, June 2013 (2013-06-01), pages 127 - 136, XP053028745
LIN ET AL.: "Combination of quercetin with radiotherapy enhances tumor radiosensitivity in vitro and in vivo", RADIOTHERAPY AND ONCOLOGY, vol. 104, 25 November 2011 (2011-11-25), pages 395 - 400, XP055344438, DOI: doi:10.1016/j.radonc.2011.10.023
ZWICKY ET AL.: "Cathepsin B expression and down-regulation by gene silencing and antisense DNA in human chondrocytes", BIOCHEMICAL JOURNAL, vol. 367, 1 October 2002 (2002-10-01), XP002273726, DOI: doi:10.1042/BJ20020210
GONDI ET AL.: "Cathepsin B as a Cancer Target", EXPERT OPINION ON THERAPEUTIC TARGETS, vol. 17, 8 January 2013 (2013-01-08), pages 281 - 291, XP055387981, DOI: doi:10.1517/14728222.2013.740461
WANG ET AL.: "Quercetin, a flavonoid with anti-inflammatory activity, suppresses the development of abdominal aortic aneurysms in mice", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 690, 19 June 2012 (2012-06-19), pages 133 - 141, XP028934368, DOI: doi:10.1016/j.ejphar.2012.06.018
ALAPATI ET AL.: "uPAR and cathepsin B knockdown inhibits radiation-induced PKC integrated integrin signaling to the cytoskeleton of glioma-initiating cells", INTERNATIONAL JOURNAL OF ONCOLOGY, 24 May 2012 (2012-05-24), pages 599 - 610, XP055580925
PIAO ET AL.: "Hyperoside Protects Cells against Gamma Ray Radiation-Induced Apoptosis in Hamster Lung Fibroblast", NATURAL PRODUCT SCIENCES, vol. 19, June 2013 (2013-06-01), pages 127 - 136, XP053028745
Attorney, Agent or Firm:
KERR, David, S. (US)
Download PDF: