Title:
COMPOSITIONS AND METHODS RELATED TO FLAVIVIRUS ENVELOPE PROTEIN DOMAIN III ANTIGENS
Document Type and Number:
WIPO Patent Application WO2004016586
Kind Code:
A3
Abstract:
The present invention concerns methods and compositions involving flavivirus envelope protein domain III antigens for the detection of virus and detection of antibodies against the virus. Such methods and compositions may be used to detect TBE serocomplex viruses or West Nile virus infection in a subject, patient, animal or biological fluid. The present invention also concerns kits for implementing such methods. In some embodiments, kits contain a recombinant TBE serocomplex virus or West Nile virus envelope protein domain III antigen.
Inventors:
BARRETT ALAN (US)
BEASLEY DAVID (US)
HOLBROOK MICHAEL (US)
BEASLEY DAVID (US)
HOLBROOK MICHAEL (US)
Application Number:
PCT/US2003/025681
Publication Date:
November 18, 2004
Filing Date:
August 18, 2003
Export Citation:
Assignee:
UNIV TEXAS (US)
BARRETT ALAN (US)
BEASLEY DAVID (US)
HOLBROOK MICHAEL (US)
BARRETT ALAN (US)
BEASLEY DAVID (US)
HOLBROOK MICHAEL (US)
International Classes:
G01N33/53; G01N33/569; (IPC1-7): G01N33/53
Foreign References:
| US6258788B1 | 2001-07-10 | |||
| US6165477A | 2000-12-26 |
Other References:
TRENT ET AL: "Solid-phase radioimmunoassay for antibodies to flavivirus structural and nonstructural proteins", INFECTION AND IMMUNITY, vol. 13, no. 5, May 1976 (1976-05-01), pages 1325 - 1333, XP002982340
KLIMS ET AL: "Prevalence of antibodies to tickborne encephalitis and West Nile flaviviruses and the clinical signs of tickborne encephalitis in dogs in the Czech Republic", VETERINARY RECORD, vol. 148, no. 1, January 2001 (2001-01-01), pages 17 - 20, XP002982372
WANG ET AL: "West Nile virus envelope protein: role in diagnosis and immunity", ANNALS NEW YORK ACADEMY OF SCIENCE, vol. 951, December 2001 (2001-12-01), pages 325 - 327, XP002961137
WANG ET AL: "Immunization of mice against West Nile virus with recombinant envelope protein", J. OF IMMUNOLOGY, vol. 167, no. 9, November 2001 (2001-11-01), pages 5273 - 5277, XP002967433
HEINZ ET AL: "The flavivirus envelope protein E: isolation of a soluble form from tickborne encephalitis virus and its crystallization", J. OF VIROLOGY, vol. 65, no. 10, October 1991 (1991-10-01), pages 5579 - 5583, XP002982371
CRILL ET AL: "Monoclonal antibodies that bind to domain III of dengue virus E glycoprotein arethe most efficient blockers of virus adsorption to Vero cells", J. OF VIROLOGY, vol. 75, no. 16, August 2001 (2001-08-01), pages 7769 - 7773, XP002982315
HEINZ ET AL: "Monoclonal antibodies to the structural glycoprotein of tick-borne encephalitis virus", INFECTION AND IMMUNITY, vol. 37, no. 3, September 1982 (1982-09-01), pages 869 - 874, XP002982316
GAUNT ET AL: "Phylogenetic relationships of flaviviruses correlate with their epidemiology, disease association and biogeography", J. OF GENERAL VIROLOGY, vol. 82, no. 8, August 2001 (2001-08-01), pages 1867 - 1876, XP002982317
NI ET AL: "Attenuation of Japanese Encephalitis Virus by Selection of Its Mouse Brain Membrane Receptor Preparation Escape Variants", J. OF GEN. VIROLOGY, vol. 241, no. 1, February 1998 (1998-02-01), pages 30 - 66, XP004446002
KUNO ET AL: "Genomic sequencing of deer tick virus and phylogeny of powassan-related viruses of North America", AM. J. OF TROPICAL MEDICINE AND HYGIENE, vol. 65, no. 5, November 2001 (2001-11-01), pages 671 - 676, XP002982318
KLIMS ET AL: "Prevalence of antibodies to tickborne encephalitis and West Nile flaviviruses and the clinical signs of tickborne encephalitis in dogs in the Czech Republic", VETERINARY RECORD, vol. 148, no. 1, January 2001 (2001-01-01), pages 17 - 20, XP002982372
WANG ET AL: "West Nile virus envelope protein: role in diagnosis and immunity", ANNALS NEW YORK ACADEMY OF SCIENCE, vol. 951, December 2001 (2001-12-01), pages 325 - 327, XP002961137
WANG ET AL: "Immunization of mice against West Nile virus with recombinant envelope protein", J. OF IMMUNOLOGY, vol. 167, no. 9, November 2001 (2001-11-01), pages 5273 - 5277, XP002967433
HEINZ ET AL: "The flavivirus envelope protein E: isolation of a soluble form from tickborne encephalitis virus and its crystallization", J. OF VIROLOGY, vol. 65, no. 10, October 1991 (1991-10-01), pages 5579 - 5583, XP002982371
CRILL ET AL: "Monoclonal antibodies that bind to domain III of dengue virus E glycoprotein arethe most efficient blockers of virus adsorption to Vero cells", J. OF VIROLOGY, vol. 75, no. 16, August 2001 (2001-08-01), pages 7769 - 7773, XP002982315
HEINZ ET AL: "Monoclonal antibodies to the structural glycoprotein of tick-borne encephalitis virus", INFECTION AND IMMUNITY, vol. 37, no. 3, September 1982 (1982-09-01), pages 869 - 874, XP002982316
GAUNT ET AL: "Phylogenetic relationships of flaviviruses correlate with their epidemiology, disease association and biogeography", J. OF GENERAL VIROLOGY, vol. 82, no. 8, August 2001 (2001-08-01), pages 1867 - 1876, XP002982317
NI ET AL: "Attenuation of Japanese Encephalitis Virus by Selection of Its Mouse Brain Membrane Receptor Preparation Escape Variants", J. OF GEN. VIROLOGY, vol. 241, no. 1, February 1998 (1998-02-01), pages 30 - 66, XP004446002
KUNO ET AL: "Genomic sequencing of deer tick virus and phylogeny of powassan-related viruses of North America", AM. J. OF TROPICAL MEDICINE AND HYGIENE, vol. 65, no. 5, November 2001 (2001-11-01), pages 671 - 676, XP002982318
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