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Title:
COMPOSITIONS AND METHODS TARGETING G12 SIGNALING FOR BRONCHODILATOR THERAPY
Document Type and Number:
WIPO Patent Application WO/2019/005503
Kind Code:
A8
Abstract:
Provided herein are methods for inhibiting contraction and/or promoting relaxation of airway smooth muscle cells (e.g., human airway smooth muscle cells), comprising contacting the cells with a Gα12 or RhoA inhibitor. Also provided herein are methods for inhibiting and/or treating bronchoconstriction or promoting bronchodilation in a subject, for example, a subject with airway hyperresponsiveness and/or a disease associated with bronchoconstriction, such as asthma, chronic obstructive pulmonary disease, chronic bronchitis, bronchiectasis or cystic fibrosis, using a Gα12 or RhoA inhibitor, as well as pharmaceutical compositions comprising a Gα12 or RhoA inhibitor.

Inventors:
PANETTIERI REYNOLD (US)
YOO EDWIN (US)
Application Number:
PCT/US2018/037773
Publication Date:
April 04, 2019
Filing Date:
June 15, 2018
Export Citation:
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Assignee:
UNIV RUTGERS (US)
International Classes:
C12N15/113; A61K31/7088
Attorney, Agent or Firm:
BALICKY, Eric, M. et al. (Brook Smith & Reynolds, P.C.,530 Virginia Rd, P.O. Box 913, Concord MA, US)
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