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Patent Searching and Data


Title:
COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE
Document Type and Number:
WIPO Patent Application WO/2021/067611
Kind Code:
A3
Abstract:
The present disclosure features methods and compositions for treating Alzheimer's disease. The disclosed methods comprise administering to a subject having or suspected of having Alzheimer's a hematopoietic stem progenitor cell expressing at least one neuroprotective agent, such as ApoE2, Trem2, and/or a metallothionein.

Inventors:
BIFFI ALESSANDRA (US)
PEVIANI MARCO (US)
Application Number:
PCT/US2020/053824
Publication Date:
May 14, 2021
Filing Date:
October 01, 2020
Export Citation:
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Assignee:
CHILDRENS MEDICAL CENTER (US)
DANA FARBER CANCER INST INC (US)
International Classes:
A61K48/00; A61K35/28; A61P25/28; C12N5/079
Domestic Patent References:
WO1996002670A11996-02-01
Foreign References:
US8093209B22012-01-10
US9339512B22016-05-17
Other References:
ATAGI ET AL.: "Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 290, no. 43, 23 October 2015 (2015-10-23), pages 26043 - 26051, XP055664659, DOI: 10.1074/jbc.M115.679043
YU ET AL.: "Metallothionein III is reduced in Alzheimer's disease", BRAIN RESEARCH, vol. 894, no. 1, 9 March 2001 (2001-03-09), pages 37 - 45, XP055821851
Attorney, Agent or Firm:
HUNTER-ENSOR, Melissa (US)
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