Title:
COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS
Document Type and Number:
WIPO Patent Application WO/2016/164763
Kind Code:
A8
Abstract:
Described herein are deuterium-enriched neuroactive steroids of the Formula (II) or a pharmaceutically acceptable salt thereof; wherein R2a, R2b, R3, R4a, R4b, R5, R6a, R6b, Rlla, Rllb, R12a, R12b, R16a, R16b, R17, R19, Ra, and Rb and subvariables thereof are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment.
Inventors:
ROBICHAUD ALBERT JEAN (US)
SALITURO FRANCESCO G (US)
MARTINEZ BOTELLA GABRIEL (US)
HARRISON BOYD L (US)
JONAS JEFFREY (US)
SALITURO FRANCESCO G (US)
MARTINEZ BOTELLA GABRIEL (US)
HARRISON BOYD L (US)
JONAS JEFFREY (US)
Application Number:
PCT/US2016/026705
Publication Date:
November 03, 2016
Filing Date:
April 08, 2016
Export Citation:
Assignee:
SAGE THERAPEUTICS INC (US)
International Classes:
A61K31/57; A61P25/00; C07J7/00
Attorney, Agent or Firm:
YEE, Dominic, Jason (LLPRiverfront Office Park,One Main Street, Suite 110, Cambridge MA, US)
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