Title:
COMPOSITIONS AND METHODS FOR THE TREATMENT OF ESTROGEN-DEPENDENT DISORDERS
Document Type and Number:
WIPO Patent Application WO/2021/023877
Kind Code:
A3
Abstract:
The present disclosure provides compositions and methods for treating estrogen-dependent disorders, such as disorders of the female reproductive system, including uterine fibroids and endometriosis, among others. Compounds described herein that may be used to treat such indications include gonadotropin-releasing hormone (GnRH) antagonists. Suitable GnRH antagonists useful in conjunction with the compositions and methods described herein include thieno[3,4d]pyrimidine derivatives, such as 3-[2-fluoro-5-(2,3-difluoro-6-methoxybenzyloxy)4-methoxyphenyI]-2,4-dioxo-1,2,3,4- tetrahydrothieno [3,4d]pyrimidine-5-carboxylic acid and the choline salt thereof, among others. Using the compositions and methods described herein, GnRH antagonists may be periodically administered to a patient, such as one or more times per day, week, or month. Advantageously, using the dosing schedules of the present disclosure, the periodic administration the GnRH antagonist may be temporarily halted, allowing a patient to recover any lost bone mineral density, without an accompanying return in the patient's symptoms.
Inventors:
GOTTELAND JEAN-PIERRE (CH)
BESTEL ELKE (CH)
BESTEL ELKE (CH)
Application Number:
PCT/EP2020/072302
Publication Date:
March 18, 2021
Filing Date:
August 07, 2020
Export Citation:
Assignee:
OBSEVA SA (CH)
International Classes:
A61K31/519; A61K31/565; A61K31/57; A61P15/00
Domestic Patent References:
| WO2018060501A2 | 2018-04-05 | |||
| WO2018224497A1 | 2018-12-13 | |||
| WO2018224498A1 | 2018-12-13 | |||
| WO2019203870A1 | 2019-10-24 | |||
| WO2020028630A1 | 2020-02-06 | |||
| WO2020094698A2 | 2020-05-14 |
Foreign References:
| US20170056403A1 | 2017-03-02 |
Attorney, Agent or Firm:
KATZAROV S.A. (CH)
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