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Title:
COMPOSITIONS FOR PREVENTION OR TREATMENT OF HEPATOPATHY
Document Type and Number:
WIPO Patent Application WO/2002/057254
Kind Code:
A1
Abstract:
Compositions for prevention or treatment of hepatopathy, containing as the active ingredient compounds represented by the general formula (I), or pharmaceutically acceptable salts, ester, or other derivatives thereof: (I) wherein A is a pyrrole ring; R?1¿ is optionally substituted aryl or optionally substituted heteroaryl; R?2¿ is optionally substituted heteroaryl; and R?3¿ is a group represented by the general formula: -X-R?4¿ [wherein X is a single bond, optionally substituted alkylene, optionally substituted alkenylene, or optionally substituted alkynylene; and R?4¿ is substituted cycloalkyl, substituted aryl, an optionally substituted heterocyclic group, optionally substituted heteroaryl, or -NR?a¿R?b¿ (wherein R?a¿ and R?b¿ are each H, alkyl, alkenyl, alkynyl, aralkyl, or alkylsulfonyl)], with the proviso that the pyrrole-constituting atoms to which R?1¿ and R?3¿ are bonded are each adjacent to the pyrrole-constituting atom to which R?2¿ is bonded.

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Inventors:
SHIMOZATO TAKAICHI (JP)
SHIMADA YOKO (JP)
KIMURA TOMIO (JP)
Application Number:
PCT/JP2002/000290
Publication Date:
July 25, 2002
Filing Date:
January 17, 2002
Export Citation:
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Assignee:
SANKYO CO (JP)
SHIMOZATO TAKAICHI (JP)
SHIMADA YOKO (JP)
KIMURA TOMIO (JP)
International Classes:
A61P1/16; C07D401/04; C07D401/14; C07D403/04; C07D451/02; C07D453/02; C07D455/02; C07D471/04; (IPC1-7): C07D401/04; A61K31/437; A61K31/4375; A61K31/439; A61K31/4439; A61K31/444; A61K31/4545; A61K31/496; A61K31/506; A61K31/5377; A61K31/541; A61P1/16; C07D401/14; C07D451/02; C07D453/02; C07D471/04
Domestic Patent References:
WO1997005877A11997-02-20
WO2000066124A12000-11-09
WO2000001688A12000-01-13
WO1997016442A11997-05-09
WO1997005878A11997-02-20
Foreign References:
EP1070711A22001-01-24
JP2001181187A2001-07-03
Other References:
See also references of EP 1352906A4
Attorney, Agent or Firm:
Ohno, Akio c/o SANKYO COMPANY (LIMITED 2-58 Hiromachi 1-chome Shinagawa-ku, Tokyo, JP)
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