Title:
COMPOUND CONTAINING 2,4-THIAZOLE RING, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/246907
Kind Code:
A1
Abstract:
Provided are a compound containing a 2,4-thiazole ring, a preparation method therefor, and an application thereof. The compound is represented by formula (X), where A is pyrazolopyrimidine or indole; Z is absent or is a carbonyl group; X is O or S; Y is -O-, -NH-, or formula (I); R1 is hydrogen or a C1-6 alkyl group; R2 is selected from a C1-C3 alkyl group, a C5-C15 alkenyl group, an alkynyl group, a 5-10 membered heterocyclic group, a C6-C12 aryl group, a 5-12 membered heteroaryl group, a sterol group, and a 5-10 membered cycloalkyl group; Y is connected to R2, or Y and R2 form a ring; R3 is selected from hydrogen, halogen, an amino group, a hydroxy group, an acetyl group, a 3-10 membered heterocyclic group, a C6-C12 aryl group, a 5-12 membered heteroaryl group, a 3-10 membered cycloalkyl group, an ester group, a carboxyl group, a trihalomethyl group, and an adamantyl group; R2 or R3 is unsubstituted or is substituted with a C1-C6 alkyl group, a hydroxy group, halogen, a trihalomethyl group, a carboxyl group, or a phenyl group; and when R2 is a C1-C3 alkyl group, R 3 is not hydrogen.
Inventors:
LOU HONGXIANG (CN)
FANG LIYUAN (CN)
SUN BIN (CN)
FANG LIYUAN (CN)
SUN BIN (CN)
Application Number:
PCT/CN2021/098707
Publication Date:
December 01, 2022
Filing Date:
June 07, 2021
Export Citation:
Assignee:
UNIV SHANDONG (CN)
International Classes:
C07D487/04; A61K31/427; A61P37/06; C07D417/06; C07D417/14; C07J21/00; C07J43/00; C07J71/00
Domestic Patent References:
| WO2020106695A1 | 2020-05-28 |
Foreign References:
| CN111587249A | 2020-08-25 | |||
| US20190284149A1 | 2019-09-19 |
Other References:
TANTAK MUKUND P.; WANG JING; SINGH RAJNISH PRAKASH; KUMAR ANIL; SHAH KAVITA; KUMAR DALIP: "2-(3′-Indolyl)-N-arylthiazole-4-carboxamides: Synthesis and evaluation of antibacterial and anticancer activi", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 25, no. 19, 6 August 2015 (2015-08-06), Amsterdam NL , pages 4225 - 4231, XP029264250, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2015.07.105
GUO HUIJUAN; RISCHER MAJA; SPERFELD MARTIN; WEIGEL CHRISTIANE; MENZEL KLAUS DIETER; CLARDY JON; BEEMELMANNS CHRISTINE: "Natural products and morphogenic activity of γ-Proteobacteria associated with the marine hydroid polypHydractinia echinata", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 25, no. 22, 1 July 2017 (2017-07-01), AMSTERDAM, NL, pages 6088 - 6097, XP085235306, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2017.06.053
RAYMOND C ROWEPAUL J SHESKEY: "Handbook of Pharmaceutical Excipients"
GUO HUIJUAN; RISCHER MAJA; SPERFELD MARTIN; WEIGEL CHRISTIANE; MENZEL KLAUS DIETER; CLARDY JON; BEEMELMANNS CHRISTINE: "Natural products and morphogenic activity of γ-Proteobacteria associated with the marine hydroid polypHydractinia echinata", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 25, no. 22, 1 July 2017 (2017-07-01), AMSTERDAM, NL, pages 6088 - 6097, XP085235306, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2017.06.053
RAYMOND C ROWEPAUL J SHESKEY: "Handbook of Pharmaceutical Excipients"
Attorney, Agent or Firm:
JINAN SHENGDA INTELLECTUAL PROPERTY AGENCY CO.,LTD. (CN)
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