Title:
COMPOUND AND DRUG CONJUGATE, AND PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/037205
Kind Code:
A1
Abstract:
Disclosed is a compound with a structure as shown in formula (101) and a corresponding drug conjugate, wherein the drug conjugate can be specifically targeted at cells and has a low toxicity and an excellent delivery efficiency.
Inventors:
ZHANG HONGYAN (CN)
YANG ZHIWEI (CN)
GAO SHAN (CN)
CAO LIQIANG (CN)
LIU GUOCHENG (CN)
YANG ZHIWEI (CN)
GAO SHAN (CN)
CAO LIQIANG (CN)
LIU GUOCHENG (CN)
Application Number:
PCT/CN2020/112105
Publication Date:
March 04, 2021
Filing Date:
August 28, 2020
Export Citation:
Assignee:
SUZHOU RIBO LIFE SCIENCE CO LTD (CN)
International Classes:
A61K31/7105; C07H15/04; A61K47/54; A61P1/16; C07H21/02; C12N15/00; C12N15/113
Domestic Patent References:
| WO2019128611A1 | 2019-07-04 | |||
| WO2016206626A1 | 2016-12-29 | |||
| WO2018223056A1 | 2018-12-06 | |||
| WO2018223073A1 | 2018-12-06 | |||
| WO2018223081A1 | 2018-12-06 | |||
| WO2011154331A1 | 2011-12-15 | |||
| WO2010012244A1 | 2010-02-04 | |||
| WO2009082607A2 | 2009-07-02 | |||
| WO2009082607A2 | 2009-07-02 | |||
| WO2009073809A2 | 2009-06-11 | |||
| WO2015006740A2 | 2015-01-15 |
Foreign References:
| CN107109405A | 2017-08-29 | |||
| CN105452465A | 2016-03-30 | |||
| CN105378082A | 2016-03-02 | |||
| US8106022B2 | 2012-01-31 |
Other References:
BEAUCAGE ET AL., TETRAHEDRON, vol. 48, 1992, pages 2223 - 2311
GREENEWUTS: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS
"Genbank", Database accession no. NM_000040.1
J.K. WATTSG.F. DELEAVEYM.J. DAMHA: "Chemically modified siRNA: tools and applications", DRUG DISCOV TODAY, vol. 13, no. 19-20, 2008, pages 842 - 55
ANASTASIA KHVOROVAJONATHAN K. WATTS: "The chemical evolution of oligonucleotide therapies of clinical utility", NATURE BIOTECHNOLOGY, vol. 35, no. 3, 2017, pages 238 - 48, XP055410409, DOI: 10.1038/nbt.3765
"Molecular Cloning", 1989, COLD SPRING HARBOR LBBORATORY PRESS
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CAS , no. 165534-43-0
CAS , no. 616-30-8
See also references of EP 4023659A4
GREENEWUTS: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS
"Genbank", Database accession no. NM_000040.1
J.K. WATTSG.F. DELEAVEYM.J. DAMHA: "Chemically modified siRNA: tools and applications", DRUG DISCOV TODAY, vol. 13, no. 19-20, 2008, pages 842 - 55
ANASTASIA KHVOROVAJONATHAN K. WATTS: "The chemical evolution of oligonucleotide therapies of clinical utility", NATURE BIOTECHNOLOGY, vol. 35, no. 3, 2017, pages 238 - 48, XP055410409, DOI: 10.1038/nbt.3765
"Molecular Cloning", 1989, COLD SPRING HARBOR LBBORATORY PRESS
REN J ET AL., J. MEDICAL VIROLOGY., vol. 78, 2006, pages 551 - 560
DONG XIAOYAN ET AL., CHIN JBIOTECH, vol. 26, no. 5, 25 May 2010 (2010-05-25), pages 679 - 686
CAS , no. 165534-43-0
CAS , no. 616-30-8
See also references of EP 4023659A4
Attorney, Agent or Firm:
PEKSUNG INTELLECTUAL PROPERTY LTD. (CN)
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