Title:
COMPOUND HAVING ENAC ACTIVATION POTENCY
Document Type and Number:
WIPO Patent Application WO/2020/059660
Kind Code:
A1
Abstract:
[Problem] The present invention addresses the problem of providing a novel hENaC αβγ activating agent. [Solution] Provided is a hENaC αβγ activating agent including, as an effective component, a compound or a salt thereof having a structure identical to or similar to 3-chloro-N-(2-((1,1-dioxidetetrahydrothiophene-3-yl)amino)-2-oxoethyl)-N-ethylbenzo[β]thiophene-2-carboxyamide, which is represented by formula (1). Utilization of this hENaC αβγ activating agent contributes to further development of drugs, the food industry, and the health sciences.
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Inventors:
KASAHARA YOICHI (JP)
Application Number:
PCT/JP2019/036105
Publication Date:
March 26, 2020
Filing Date:
September 13, 2019
Export Citation:
Assignee:
NISSIN FOODS HOLDINGS CO LTD (JP)
International Classes:
A61K31/381; A61P1/12; A61P11/00; A61P13/12; A61P43/00
Domestic Patent References:
WO2009106980A2 | 2009-09-03 |
Foreign References:
JP2014503473A | 2014-02-13 | |||
JP2010523579A | 2010-07-15 | |||
JPH07179430A | 1995-07-18 |
Other References:
DATABASE CHEMCATS REGISTRY [online] 17 January 2006 (2006-01-17), "CN : Benzo[b]thiophene-2-carboxamide,3-chloro-N-ethyl-N- [2-oxo-2-[(tetrahydro-1, 1-dioxido-3-thienyl)amino]ethyl]- ( CA INDEX NAME) SR: Chemical Library, Supplier: Enamine", retrieved from STN Database accession no. 872024-60-7
CARPINO, L A ET AL.: "The 1,1-Dioxobenzo[b]thiophene-2-ylmethyloxycarbonyl (Bsmoc) amino-protecting group", JOURNAL OF ORGANIC CHEMISTRY, vol. 64, no. 12, 1999, pages 4324 - 4338, XP002203970, DOI: 10.1021/jo982140l
DATABASE CHEMCATS REGISTRY [online] 22 August 2008 (2008-08-22), "CN : Benzo[b]thiophene-2-carboxamide, 3-chloro-N- [2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-N-ethyl- ( CA INDEX NAME) SR: Chemical Library, Supplier: UkrOrgSynthesis", retrieved from STN Database accession no. 1042881-47-9
DATABASE CHEMCATS REGISTRY [online] 24 March 2006 (2006-03-24), "CN : Benzo[b]thiophene-2-carboxamide, N-ethyl-4-fluoro-N- [2-oxo-2-[(tetrahydro-1, 1-dioxido-3-thienyl)amino]ethyl]- ( CA INDEX NAME) SR: Chemical Library, Supplier: Enamine", retrieved from STN Database accession no. 877982-06-4
DATABASE CHEMCATS REGISTRY [online] 4 April 2006 (2006-04-04), "CN :Benzamide, N-ethyl-N-[2-oxo-2-[(tetrahydro-1, l-dioxido-3- thienyl)amino]ethyl]-2-(phenylmethyl)- ( CA INDEX NAME) SR: Chemical Library, Supplier: Enamine", retrieved from STN Database accession no. 879192-60-6
DATABASE CHEMCATS REGISTRY [online] 11 January 2006 (2006-01-11), "CN : Cyclobutanecarboxamide, 1-(4-chlorophenyl)-N-ethyl-N- [2-oxo-2-[(tetrahydro-1, l-dioxido-3-thienyl)amino]ethyl]- ( CA INDEX NAME) SR: Chemical Library, Supplier: Enamine", retrieved from STN Database accession no. 871666-13-6
"Screening of human ENaC activating agent by using chemical library", HUMAN ENAC, vol. 2019, 5 March 2019 (2019-03-05)
CARPINO, L A ET AL.: "The 1,1-Dioxobenzo[b]thiophene-2-ylmethyloxycarbonyl (Bsmoc) amino-protecting group", JOURNAL OF ORGANIC CHEMISTRY, vol. 64, no. 12, 1999, pages 4324 - 4338, XP002203970, DOI: 10.1021/jo982140l
DATABASE CHEMCATS REGISTRY [online] 22 August 2008 (2008-08-22), "CN : Benzo[b]thiophene-2-carboxamide, 3-chloro-N- [2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-N-ethyl- ( CA INDEX NAME) SR: Chemical Library, Supplier: UkrOrgSynthesis", retrieved from STN Database accession no. 1042881-47-9
DATABASE CHEMCATS REGISTRY [online] 24 March 2006 (2006-03-24), "CN : Benzo[b]thiophene-2-carboxamide, N-ethyl-4-fluoro-N- [2-oxo-2-[(tetrahydro-1, 1-dioxido-3-thienyl)amino]ethyl]- ( CA INDEX NAME) SR: Chemical Library, Supplier: Enamine", retrieved from STN Database accession no. 877982-06-4
DATABASE CHEMCATS REGISTRY [online] 4 April 2006 (2006-04-04), "CN :Benzamide, N-ethyl-N-[2-oxo-2-[(tetrahydro-1, l-dioxido-3- thienyl)amino]ethyl]-2-(phenylmethyl)- ( CA INDEX NAME) SR: Chemical Library, Supplier: Enamine", retrieved from STN Database accession no. 879192-60-6
DATABASE CHEMCATS REGISTRY [online] 11 January 2006 (2006-01-11), "CN : Cyclobutanecarboxamide, 1-(4-chlorophenyl)-N-ethyl-N- [2-oxo-2-[(tetrahydro-1, l-dioxido-3-thienyl)amino]ethyl]- ( CA INDEX NAME) SR: Chemical Library, Supplier: Enamine", retrieved from STN Database accession no. 871666-13-6
"Screening of human ENaC activating agent by using chemical library", HUMAN ENAC, vol. 2019, 5 March 2019 (2019-03-05)
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