Title:
COMPOUND FOR PREVENTING AND TREATING INFLAMMATION, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/160455
Kind Code:
A1
Abstract:
The present invention relates to the field of natural medicines, and particularly provides a compound for preventing and treating inflammation. The compound has a structure, as shown in formulas I-VIII, and belongs to a 2-(2-phenethyl) chromone compound. Anti-inflammatory activity evaluation is performed by means of LPS-induced RAW 264.7 for generating NO as a model, and the compound, as shown in formulas I-VIII, can inhibit the generation of NO, which reflects the anti-inflammatory activity. Therefore, the compound can be used for preparing foods and/or medicines for preventing, treating and/or alleviating inflammation.
Inventors:
YANG LI (CN)
DONG WENHUA (CN)
MEI WENLI (CN)
DAI HAOFU (CN)
CHEN HUIQIN (CN)
WEI YANMEI (CN)
DONG WENHUA (CN)
MEI WENLI (CN)
DAI HAOFU (CN)
CHEN HUIQIN (CN)
WEI YANMEI (CN)
Application Number:
PCT/CN2021/083891
Publication Date:
August 04, 2022
Filing Date:
March 30, 2021
Export Citation:
Assignee:
INST TROPICAL BIOSCIENCE & BIOTECHNOLOGY CATAS (CN)
International Classes:
C07D311/22; A61K31/352; A61P29/00
Foreign References:
| CN107034252A | 2017-08-11 | |||
| CN106309423A | 2017-01-11 | |||
| CN110818669A | 2020-02-21 | |||
| JP2017088571A | 2017-05-25 |
Other References:
WANG SIN-LING, HWANG TSONG-LONG, CHUNG MEI-ING, SUNG PING-JYUN, SHU CHIH-WEN, CHENG MING-JEN, CHEN JIH-JUNG: "New Flavones, a 2-(2-Phenylethyl)-4H-chromen-4-one Derivative, and Anti-Inflammatory Constituents from the Stem Barks of Aquilaria sinensis", MOLECULES, vol. 20, no. 11, 24 November 2015 (2015-11-24), pages 20912 - 20925, XP055954945, DOI: 10.3390/molecules201119736
GAO MEI, XIAOMIN HAN, JUNQING HUANG, YING SUN, YANGYANG LIU, HONGJIANG CHEN, YUE JIN, YUN YANG, ZHIHUI GAO, YANHONG XU, ZHENG ZHAN: "Simultaneous Determination of Multiple Active 2-(2-Phenylethyl)Chromone Analogues in Agarwood by HPLC, QAMS, and UPLC-MS", PHYTOCHEMICAL ANALYSIS, vol. 32, no. 3, 16 September 2020 (2020-09-16), pages 412 - 422, XP055954946, DOI: 10.1002/pca.2989
SHAO HANG, MEI WEN-LI, DONG WEN-HUA, GAI CUI-JUAN, LI WEI, ZHU GUO-PENG, DAI HAO-FU: "2-(2-Phenylethyl)chromone Derivatives of Agarwood Originating from Gyrinops salicifolia", MOLECULES, vol. 21, no. 10, 3 October 2016 (2016-10-03), pages 1313, XP055954948, DOI: 10.3390/molecules21101313
GAO MEI, XIAOMIN HAN, JUNQING HUANG, YING SUN, YANGYANG LIU, HONGJIANG CHEN, YUE JIN, YUN YANG, ZHIHUI GAO, YANHONG XU, ZHENG ZHAN: "Simultaneous Determination of Multiple Active 2-(2-Phenylethyl)Chromone Analogues in Agarwood by HPLC, QAMS, and UPLC-MS", PHYTOCHEMICAL ANALYSIS, vol. 32, no. 3, 16 September 2020 (2020-09-16), pages 412 - 422, XP055954946, DOI: 10.1002/pca.2989
SHAO HANG, MEI WEN-LI, DONG WEN-HUA, GAI CUI-JUAN, LI WEI, ZHU GUO-PENG, DAI HAO-FU: "2-(2-Phenylethyl)chromone Derivatives of Agarwood Originating from Gyrinops salicifolia", MOLECULES, vol. 21, no. 10, 3 October 2016 (2016-10-03), pages 1313, XP055954948, DOI: 10.3390/molecules21101313
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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