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Title:
COMPOUND OR SALT THEREOF, AND ANTIBODY OBTAINED THEREFROM
Document Type and Number:
WIPO Patent Application WO/2022/154127
Kind Code:
A1
Abstract:
The present invention provides a desired antibody or antibody composition by modifying a thiol group chemically introduced into an antibody. More specifically, the present invention provides an antibody composition, etc., having desired properties, the antibody composition comprising (A) an antibody intermediate having an optionally protected bioorthogonal functional group represented by formula (A) (in the formula, Ab is a prescribed antibody, S is a sulfur atom, L is a divalent group, R is an optionally protected bioorthogonal functional group, and n is an integer of 1-8) or a salt thereof, and (B) a thiol-group-introduced antibody represented by formula (B) (in the formula, Ab and n are the same as in formula (A), and SH is a thiol group) or a salt thereof.

Inventors:
FUJII TOMOHIRO (JP)
YAMADA KEI (JP)
MATSUDA YUTAKA (JP)
HIRAMA RYUSUKE (JP)
HATADA NORIKO (JP)
Application Number:
PCT/JP2022/001617
Publication Date:
July 21, 2022
Filing Date:
January 18, 2022
Export Citation:
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Assignee:
AJINOMOTO KK (JP)
International Classes:
C07K16/00; A61K39/395; A61K47/54; A61K47/65; A61K47/68; A61P43/00; C07K1/00; C07K14/00; C07K19/00; C12N15/13; C12P21/08
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Attorney, Agent or Firm:
SAKAI INTERNATIONAL PATENT OFFICE (JP)
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