Title:
COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH LPA RECEPTOR ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2022/083703
Kind Code:
A1
Abstract:
This disclosure relates to LPA antagonists of Formula (I) : including pharmaceutically acceptable salts and solvates thereof, and pharmaceutical compositions including the same.
Inventors:
ZHANG HAIZHEN (CN)
HANSON MICHAEL (US)
JENNINGS ANDREW (US)
LEI HUI (CN)
LIN XICHEN (CN)
ZHANG QIONG (CN)
COTE ALEXANDRE (CA)
RUVINSKY ANATOLY M (US)
HANSON MICHAEL (US)
JENNINGS ANDREW (US)
LEI HUI (CN)
LIN XICHEN (CN)
ZHANG QIONG (CN)
COTE ALEXANDRE (CA)
RUVINSKY ANATOLY M (US)
Application Number:
PCT/CN2021/125409
Publication Date:
April 28, 2022
Filing Date:
October 21, 2021
Export Citation:
Assignee:
LHOTSE BIO INC (US)
ZHANG HAIZHEN (CN)
ZHANG HAIZHEN (CN)
International Classes:
C07D207/416; A61K31/40; A61K31/415; A61K31/44; A61P1/16; A61P13/12; A61P19/10; A61P29/00; A61P35/00; C07D213/30; C07D213/64; C07D231/12; C07D231/14; C07D235/16; C07D277/587; C07D401/06; C07D413/04; C07D417/04; C07D471/04
Domestic Patent References:
| WO2017223016A1 | 2017-12-28 |
Other References:
FUJIWARA ET AL., J BIOL. CHEM., vol. 280, 2005, pages 35038 - 35050
LIPINSKI: "Bioisosterism In Drug Design", ANNUAL REPORTS IN MEDICINAL CHEMISTRY, vol. 21, 1986, pages 283
YUN, HWAHAK SEKYE, APPLICATION OF BIOISOSTERISM TO NEW DRUG DESIGN, vol. 33, 1993, pages 576 - 579
ZHAO, HUAXUE TONGBAO, BIOISOSTERIC REPLACEMENT AND DEVELOPMENT OF LEAD COMPOUNDS IN DRUG DESIGN, vol. 25, 1995, pages 34 - 38
GRAHAM, THEOCHEM, THEORETICAL STUDIES APPLIED TO DRUG DESIGN:AB INITIO ELECTRONIC DISTRIBUTIONS IN BIOISOSTERES, vol. 343, 1995, pages 105 - 109
"Remington: The Science and Practice of Pharmacy", 2012, LIPPINCOTT WILLIAMS & WILKINS
"The Pharmaceutical Press and the American Pharmaceutical Association", 2009, CRC PRESS LLC
"Handbook of Pharmaceutical Additives", 2007, GOWER PUBLISHING COMPANY
YAMADA, CANCER SCI, vol. 1-2, no. 8, 2008, pages 1603 - 1610
BOUCHARABA ET AL., J CLIN. INVEST., vol. 114, no. 12, 2004, pages 1714 - 1725
BOUCHARABA ET AL., PROC. NATL. ACAD SCI., vol. 103, no. 25, 2006, pages 9643 - 9648
LIPINSKI: "Bioisosterism In Drug Design", ANNUAL REPORTS IN MEDICINAL CHEMISTRY, vol. 21, 1986, pages 283
YUN, HWAHAK SEKYE, APPLICATION OF BIOISOSTERISM TO NEW DRUG DESIGN, vol. 33, 1993, pages 576 - 579
ZHAO, HUAXUE TONGBAO, BIOISOSTERIC REPLACEMENT AND DEVELOPMENT OF LEAD COMPOUNDS IN DRUG DESIGN, vol. 25, 1995, pages 34 - 38
GRAHAM, THEOCHEM, THEORETICAL STUDIES APPLIED TO DRUG DESIGN:AB INITIO ELECTRONIC DISTRIBUTIONS IN BIOISOSTERES, vol. 343, 1995, pages 105 - 109
"Remington: The Science and Practice of Pharmacy", 2012, LIPPINCOTT WILLIAMS & WILKINS
"The Pharmaceutical Press and the American Pharmaceutical Association", 2009, CRC PRESS LLC
"Handbook of Pharmaceutical Additives", 2007, GOWER PUBLISHING COMPANY
YAMADA, CANCER SCI, vol. 1-2, no. 8, 2008, pages 1603 - 1610
BOUCHARABA ET AL., J CLIN. INVEST., vol. 114, no. 12, 2004, pages 1714 - 1725
BOUCHARABA ET AL., PROC. NATL. ACAD SCI., vol. 103, no. 25, 2006, pages 9643 - 9648
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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