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Title:
COMPOUNDS AND METHODS FOR MODULATION OF ESTROGEN RECEPTORS
Document Type and Number:
WIPO Patent Application WO2000055137
Kind Code:
A8
Abstract:
Compounds that modulate the estrogen receptor (ER) are disclosed, as well as pharmaceutical compositions containing the same. In a specific embodiment, the compounds are selective modulators for ER- beta over ER- alpha . Methods are disclosed for modulating ER- beta in cell and/or tissues expressing the same, including cells and/or tissue that preferentially express ER- beta . More generally, methods for treating estrogen-related conditions are also disclosed, including conditions such as is breast cancer, testicular cancer, osteoporosis, endometriosis, cardiovascular disease, hypercholesterolemia, prostatic hypertrophy, prostatic carcinomas, obesity, hot flashes, skin effects, mood swings, memory loss, urinary incontinence, hairloss, cataracts, natural hormonal imbalances, and adverse reproductive effects associated with exposure to environmental chemicals.

Inventors:
BHAGWAT SHRIPAD S (US)
GAYO LEAH-FUNG M (US)
STEIN BERND (US)
CHAO QI (US)
GANGLOFF ANTHONY (US)
MCKIE JEFFREY (US)
RICE KEN (US)
Application Number:
PCT/US2000/007109
Publication Date:
July 05, 2001
Filing Date:
March 17, 2000
Export Citation:
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Assignee:
SIGNAL PHARM INC (US)
AXYS PHARM INC (US)
BHAGWAT SHRIPAD S (US)
GAYO LEAH FUNG M (US)
STEIN BERND (US)
CHAO QI (US)
GANGLOFF ANTHONY (US)
MCKIE JEFFREY (US)
RICE KEN (US)
International Classes:
A61K31/4035; A61K31/454; A61K31/472; A61K31/4725; A61K31/496; A61K31/506; A61K31/5377; A61K31/541; A61K31/55; A61P3/04; A61P3/06; A61P3/10; A61P5/00; A61P9/00; A61P9/14; A61P13/02; A61P13/08; A61P15/00; A61P15/12; A61P17/00; A61P17/02; A61P19/00; A61P25/00; A61P25/28; A61P27/12; A61P35/00; A61P43/00; C07D209/44; C07D217/04; C07D217/16; C07D217/18; C07D217/20; C07D223/16; C07D401/04; C07D401/06; C07D401/12; C07D405/04; C07D405/12; C07D413/12; C07D417/12; (IPC1-7): C07D217/18; C07D217/04; C07D217/20; C07D223/16; C07D209/44; C07D401/04; C07D401/06; C07D401/12; C07D405/04; A61K31/472; A61P35/00
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