Title:
COMPOUNDS FOR THE MODULATION OF PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9)
Document Type and Number:
WIPO Patent Application WO/2020/252383
Kind Code:
A3
Abstract:
The present disclosure relates to novel compounds capable of binding to PCSK9, thereby modulating PCSK9 biological activity. Also provided are compositions comprising these compounds, methods of preparing the compounds, and methods for use of the compounds in the treatment of PCSK9-related conditions and diseases.
Inventors:
BOWERS SIMEON (US)
KARBARZ MARK (US)
ZHU JIANG (US)
BARTA THOMAS E (US)
BOURNE JONATHAN WILLIAM (US)
PANDEY ANJALI (US)
KARBARZ MARK (US)
ZHU JIANG (US)
BARTA THOMAS E (US)
BOURNE JONATHAN WILLIAM (US)
PANDEY ANJALI (US)
Application Number:
PCT/US2020/037591
Publication Date:
March 18, 2021
Filing Date:
June 12, 2020
Export Citation:
Assignee:
SRX CARDIO LLC (US)
International Classes:
C07D253/02; A61K31/53
Domestic Patent References:
| WO2018165718A1 | 2018-09-20 |
Foreign References:
| US20070207985A1 | 2007-09-06 | |||
| US20180250291A1 | 2018-09-06 |
Other References:
DATABASE PUBCHEM 15 December 2018 (2018-12-15), "5-Cyclooctyl-3-methyl-1,2,4-triazine | C12H19N3", XP055803906, retrieved from NCBI Database accession no. 135243294
DATABASE Pubchem Compound 20 October 2014 (2014-10-20), "(5-Cyclopentyl-1,2,4-triazin-3-yl)methanamine | C9H14N4", XP055803910, retrieved from NCBI Database accession no. 84050476
DATABASE Pubchem Compound 20 October 2014 (2014-10-20), "(5-Cyclopentyl-1,2,4-triazin-3-yl)methanamine | C9H14N4", XP055803910, retrieved from NCBI Database accession no. 84050476
Attorney, Agent or Firm:
TANNER, Lorna L. et al. (US)
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