COMPOUNDS WITH ANALGESIC ACTIVITY AND MEDICAL USE THEREOF

Title:

COMPOUNDS WITH ANALGESIC ACTIVITY AND MEDICAL USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2015/101294

Kind Code:

A1

Abstract:

The present invention provides compounds of general formula I, isomers thereof, non-toxic pharmaceutically acceptable salts or solvates thereof. The compounds have remarkably strengthened analgesic activity, reduce the acute toxicity obviously, have no inhibition to heart Herg channel, and reduce side effects on coordination movement of mice remarkably. The present invention realizes the separation of activity and side effects, and has a good application prospect.

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Inventors:

ZHONG BOHUA (CN)
ZHANG PING (CN)
SHI WEIGUO (CN)
JIA HONGXIN (CN)
FAN SHIYONG (CN)
YAO YISHAN (CN)
FU RENFANG (CN)

Application Number:

PCT/CN2014/095618

Publication Date:

July 09, 2015

Filing Date:

December 30, 2014

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Assignee:

INST PHARM & TOXICOLOGY AMMS (CN)

International Classes:

C07D317/64; A61K31/36; A61P29/00

Foreign References:

US6500825B2	2002-12-31
CN103804341A	2014-05-21

Attorney, Agent or Firm:

CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
中国国际贸易促进委员会专利商标事务所 (CN)

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