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Patent Searching and Data


Title:
COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2012/085668
Kind Code:
A3
Abstract:
The invention provides a synthetic C. difficile PS-II cell wall saccharide. The invention also provides a process for purifying C. difficile PS-II saccharide from C. difficile bacterial cells resulting in reduced contamination. The saccharides may be used in vaccines, particularly as conjugates with carrier proteins.

Inventors:
COSTANTINO PAOLO (IT)
ADAMO ROBERTO (IT)
ROMANO MARIA ROSARIA (IT)
DANIEL ELISA (IT)
BERTI FRANCESCO (IT)
CAPPELLITTI EMILIA (IT)
LAY LUIGI (IT)
Application Number:
PCT/IB2011/003244
Publication Date:
August 01, 2013
Filing Date:
December 23, 2011
Export Citation:
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Assignee:
NOVARTIS AG (CH)
COSTANTINO PAOLO (IT)
ADAMO ROBERTO (IT)
ROMANO MARIA ROSARIA (IT)
DANIEL ELISA (IT)
BERTI FRANCESCO (IT)
CAPPELLITTI EMILIA (IT)
LAY LUIGI (IT)
International Classes:
C07H15/04; A61K39/08; A61K39/40; A61K39/44; A61K47/48; A61P1/12; A61P31/04; C07H15/18; C08B37/00; C08L5/00; C12P19/04
Domestic Patent References:
WO2009033268A12009-03-19
WO2012119769A12012-09-13
Foreign References:
Other References:
ELISA DANIELI ET AL: "First Synthesis of C. difficile PS-II Cell Wall Polysaccharide Repeating Unit", ORGANIC LETTERS, vol. 13, no. 3, 29 December 2010 (2010-12-29), pages 378 - 381, XP055025457, ISSN: 1523-7060, DOI: 10.1021/ol1026188
MATTHIAS A. OBERLI ET AL: "A Possible Oligosaccharide-Conjugate Vaccine Candidate for Clostridium difficile Is Antigenic and Immunogenic", CHEMISTRY & BIOLOGY, vol. 18, no. 5, 26 May 2011 (2011-05-26), pages 580 - 588, XP055007928, ISSN: 1074-5521, DOI: 10.1016/j.chembiol.2011.03.009
OLGA MARTÍNEZ-ÁVILA ET AL: "Gold Manno -Glyconanoparticles: Multivalent Systems to Block HIV-1 gp120 Binding to the Lectin DC-SIGN", CHEMISTRY - A EUROPEAN JOURNAL, vol. 15, no. 38, 28 September 2009 (2009-09-28), pages 9874 - 9888, XP055055959, ISSN: 0947-6539, DOI: 10.1002/chem.200900923
GANESHAPILLAI ET AL: "Clostridium difficile cell-surface polysaccharides composed of pentaglycosyl and hexaglycosyl phosphate repeating units", 12 January 2008, CARBOHYDRATE RESEARCH, PERGAMON, GB, PAGE(S) 703 - 710, ISSN: 0008-6215, XP022497595
Attorney, Agent or Firm:
MARSHALL, Cameron, John et al. (One Southampton Row, London WC1B 5HA, GB)
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