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Patent Searching and Data


Title:
CONJUGATE BASED SYSTEMS FOR CONTROLLED INSULIN DELIVERY
Document Type and Number:
WIPO Patent Application WO/2019/125879
Kind Code:
A3
Abstract:
The present disclosure provides conjugates which comprise an insulin molecule conjugated via a conjugate framework to one or more separate ligands that include a first saccharide, and wherein the conjugate framework also comprises a fatty chain (e.g., a C8-30 fatty chain). In certain embodiments, a conjugate is characterized in that, when the conjugate is administered to a mammal, at least one pharmacokinetic (PK) and/or pharmacodynamic (PD) property of the conjugate is sensitive to serum concentration of a second saccharide. In certain embodiments, a conjugate is also characterized by having a protracted PK profile. Exemplary conjugates and sustained release formulations are provided in addition to methods of use and preparation.

Inventors:
YAN LIN (US)
HUO PEI (US)
KEKEC AHMET (US)
ZHU YUPING (US)
PISSARNITSKI DMITRI (US)
FENG DANQING (US)
MOYES CHRIS (US)
ZHAO ZHIQIANG (US)
HUNTER DAVID (US)
LIN SONGNIAN (US)
LANCASTER THOMAS (US)
CHEN BENJAMIN (US)
Application Number:
PCT/US2018/065321
Publication Date:
April 02, 2020
Filing Date:
December 13, 2018
Export Citation:
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Assignee:
MERCK SHARP & DOHME (US)
SMARTCELLS INC (US)
YAN LIN (US)
HUO PEI (US)
KEKEC AHMET (US)
ZHU YUPING (US)
PISSARNITSKI DMITRI (US)
FENG DANQING D (US)
MOYES CHRIS (US)
ZHAO ZHIQIANG (US)
HUNTER DAVID N (US)
LIN SONGNIAN (US)
LANCASTER THOMAS M (US)
CHEN BENJAMIN (US)
International Classes:
A61K31/70; A61K38/28; A61K47/50; C07H15/02; C07H15/04; C07K14/62
Domestic Patent References:
WO2016164288A12016-10-13
Foreign References:
US20150105317A12015-04-16
US20120010134A12012-01-12
Attorney, Agent or Firm:
MERCK SHARP & DOHME CORP. (US)
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