Title:
GFRα1-CONTAINING NEURITE OUTGROWTH PROMOTER AND PHARMACEUTICAL COMPOSITION FOR INDUCING NERVE REGENERATION
Document Type and Number:
WIPO Patent Application WO/2022/138984
Kind Code:
A1
Abstract:
The present invention provides a neurite outgrowth promoter for promoting neurite growth on nerve cells of a postnatal mammalian individual for use in a condition in which an effective amount of a glial cell-derived neurotrophic factor (GDNF) is not present, the neurite outgrowth promoter containing at least one protein selected from the group consisting of: GDNF family receptor α1 (GFRα1); GFRα1 mutants having an amino acid sequence that has at least 90% sequence identity with the amino acid sequence of GFRα1, the GFRα1 mutants having neurite outgrowth activity; fusion proteins that have neurite outgrowth activity and that are obtained by fusing GFRα1 or a GFRα1 mutant with another peptide; and chemically modified proteins that have neurite outgrowth activity and that are obtained by chemically modifying one or a plurality of amino acid residues in GFRα1, a GFRα1 mutant, or a fusion protein. The present invention also provides a pharmaceutical composition for inducing nerve regeneration.
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Inventors:
KADOYA KEN (JP)
SUZUKI TOMOAKI (JP)
ENDO TAKESHI (JP)
SUZUKI TOMOAKI (JP)
ENDO TAKESHI (JP)
Application Number:
PCT/JP2021/048612
Publication Date:
June 30, 2022
Filing Date:
December 27, 2021
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
A61K39/395; A61K31/7088; A61K38/16; A61K38/17; A61K47/50; A61K48/00; A61L27/02; A61L27/12; A61L27/16; A61L27/18; A61L27/20; A61L27/22; A61L27/24; A61L27/52; A61L27/54; A61L27/58; A61P25/00; A61P43/00; C07K14/71; C07K16/22; C07K17/04; C07K19/00; C12N15/113; C12N15/12; C12N15/13; C12N15/62
Other References:
MIKAELS-EDMAN ASA, ET AL.: "Soluble and Bound Forms of GFRα1 Elicit Different GDNF-Independent Neurite Growth Responses in Primary Sensory Neurons", DEVELOPMENTAL DYNAMICS, vol. 227, no. 1, 12 March 2003 (2003-03-12), pages 27 - 34, XP055946464, DOI: 10.1002/dvdy.10280
YOONG, L.F. ; WAN, G. ; TOO, H.P.: "GDNF-induced cell signaling and neurite outgrowths are differentially mediated by GFRalpha1 isoforms", MOLECULAR AND CELLULAR NEUROSCIENCES., SAN DIEGO, US, vol. 41, no. 4, 1 July 2009 (2009-07-01), US , pages 464 - 473, XP026196822, ISSN: 1044-7431, DOI: 10.1016/j.mcn.2009.05.002
CAO, J.P. ; WANG, H.J. ; YU, J.K. ; YANG, H. ; XIAO, C.H. ; GAO, D.S.: "Involvement of NCAM in the effects of GDNF on the neurite outgrowth in the dopamine neurons", NEUROSCIENCE RESEARCH., ELSEVIER, SHANNON., IR, vol. 61, no. 4, 1 August 2008 (2008-08-01), IR , pages 390 - 397, XP022758350, ISSN: 0168-0102, DOI: 10.1016/j.neures.2008.04.008
IBANEZ CARLOS F.; PARATCHA GUSTAVO; LEDDA FERNANDA: "RET-independent signaling by GDNF ligands and GFRα receptors", CELL AND TISSUE RESEARCH, SPRINGER, DE, vol. 382, no. 1, 31 July 2020 (2020-07-31), DE , pages 71 - 82, XP037261287, ISSN: 0302-766X, DOI: 10.1007/s00441-020-03261-2
SUZUKI, TOMOAKI ET AL.: "1-I-4-5 Effect of novel axon regeneration factor GFR alpha 1 on peripheral nerve regeneration and its molecular mechanism", THE 140TH HOKKAIDO SOCIETY OF ORTHOPAEDICS AND TRAUMATOLOGY; JUNE 5-6, 2021, HOKKAIDO SOCIETY OF ORTHOPAEDICS AND TRAUMATOLOGY, JP, 27 May 2021 (2021-05-27) - 6 June 2021 (2021-06-06), JP, pages 14, XP009538549
YOONG, L.F. ; WAN, G. ; TOO, H.P.: "GDNF-induced cell signaling and neurite outgrowths are differentially mediated by GFRalpha1 isoforms", MOLECULAR AND CELLULAR NEUROSCIENCES., SAN DIEGO, US, vol. 41, no. 4, 1 July 2009 (2009-07-01), US , pages 464 - 473, XP026196822, ISSN: 1044-7431, DOI: 10.1016/j.mcn.2009.05.002
CAO, J.P. ; WANG, H.J. ; YU, J.K. ; YANG, H. ; XIAO, C.H. ; GAO, D.S.: "Involvement of NCAM in the effects of GDNF on the neurite outgrowth in the dopamine neurons", NEUROSCIENCE RESEARCH., ELSEVIER, SHANNON., IR, vol. 61, no. 4, 1 August 2008 (2008-08-01), IR , pages 390 - 397, XP022758350, ISSN: 0168-0102, DOI: 10.1016/j.neures.2008.04.008
IBANEZ CARLOS F.; PARATCHA GUSTAVO; LEDDA FERNANDA: "RET-independent signaling by GDNF ligands and GFRα receptors", CELL AND TISSUE RESEARCH, SPRINGER, DE, vol. 382, no. 1, 31 July 2020 (2020-07-31), DE , pages 71 - 82, XP037261287, ISSN: 0302-766X, DOI: 10.1007/s00441-020-03261-2
SUZUKI, TOMOAKI ET AL.: "1-I-4-5 Effect of novel axon regeneration factor GFR alpha 1 on peripheral nerve regeneration and its molecular mechanism", THE 140TH HOKKAIDO SOCIETY OF ORTHOPAEDICS AND TRAUMATOLOGY; JUNE 5-6, 2021, HOKKAIDO SOCIETY OF ORTHOPAEDICS AND TRAUMATOLOGY, JP, 27 May 2021 (2021-05-27) - 6 June 2021 (2021-06-06), JP, pages 14, XP009538549
Attorney, Agent or Firm:
IP-ASSIST PATENT OFFICE (JP)
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