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Title:
CORROSION-RESISTANT ANTIBACTERIAL COATING FOR ARTIFICIAL ORGAN, AND PREPARATION METHOD FOR COATING
Document Type and Number:
WIPO Patent Application WO/2023/039935
Kind Code:
A1
Abstract:
Disclosed are a corrosion-resistant antibacterial coating for an artificial organ, and a preparation method for the coating. The coating is a polypeptide single-layer film with a diepoxy quaternary ammonium salt and a maleopimaric acid quaternary ammonium salt grafted thereon, wherein the grafting rate of the diepoxy quaternary ammonium salt is 3%-4%, the grafting rate of the maleopimaric acid quaternary ammonium salt is 2%-3%, the contact angle of the coating is 60°-75°, the antibacterial rate of the coating against Escherichia coli is 93%-99%, and the antibacterial rate of the coating against Staphylococcus aureus is 94%-100%. The maleopimaric acid quaternary ammonium salt and the diepoxy quaternary ammonium salt are grafted on the surface of a polypeptide monomolecular film, which enables a material to have a good antibacterial performance, and the defects in the prior art of a small-molecule quaternary ammonium salt as an antibacterial component being easily dissolved and the grafting rate of a high-molecular quaternary ammonium salt being low are overcome. Compared with grafting a single type of quaternary ammonium salt, grafting both a maleopimaric acid quaternary ammonium salt and a diepoxy quaternary ammonium salt can improve the antibacterial property of a material and can improve the corrosion resistance.

Inventors:
XU JING (CN)
GAO CHUNHONG (CN)
LI TIANDUO (CN)
BAN QING (CN)
Application Number:
PCT/CN2021/120759
Publication Date:
March 23, 2023
Filing Date:
September 26, 2021
Export Citation:
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Assignee:
UNIV QILU TECHNOLOGY (CN)
International Classes:
A61L2/232; C09D5/08; C09D5/14
Foreign References:
CN111888532A2020-11-06
CN111671970A2020-09-18
CN111671971A2020-09-18
CN110734566A2020-01-31
CN108384906A2018-08-10
CN103505759A2014-01-15
CN103436169A2013-12-11
CN110845526A2020-02-28
US4883828A1989-11-28
US20070166344A12007-07-19
Attorney, Agent or Firm:
ZHUSEN INTELLECTUAL PROPERTY AGENCY OFFICE (CN)
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