Title:
CREATION OF PEPTIDE-BASED ANTI-TUMOR AGENT
Document Type and Number:
WIPO Patent Application WO/2019/151439
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an echinomycin derivative having anti-cancer activity equal to or greater than that of echinomycin, and a production method therefor based on a chemical procedure. Provided are an echinomycin derivative represented by formula (I), and a production method therefor based on a chemical procedure.
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Inventors:
ICHIKAWA SATOSHI (JP)
KOJIMA KEITA (JP)
FUJIYA MIKIHIRO (JP)
KONISHI HIROAKI (JP)
KOJIMA KEITA (JP)
FUJIYA MIKIHIRO (JP)
KONISHI HIROAKI (JP)
Application Number:
PCT/JP2019/003482
Publication Date:
August 08, 2019
Filing Date:
January 31, 2019
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
NATIONAL UNIV CORPORATION ASAHIKAWA MEDICAL UNIV (JP)
NATIONAL UNIV CORPORATION ASAHIKAWA MEDICAL UNIV (JP)
International Classes:
C07K11/02; A61K38/12; A61P35/00
Foreign References:
| US20090053769A1 | 2009-02-26 | |||
| JP2018015606A | 2018-02-01 | |||
| US20140187546A1 | 2014-07-03 |
Other References:
KIM YUN BONG ET AL.: "Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 2, January 2004 (2004-01-01), pages 541 - 544, XP055630644
HATTORI KOZO ET AL.: "Solution-Phase Synthesis and Biological Evaluation of Triostin A and its Analogues", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 14, no. 6, 2016, pages 2090 - 2111, XP055630686
CANCER CHEMOTHER. PHARMACOL., vol. 34, 1994, pages 266 - 269
CANCER RES., vol. 19, 2005, pages 99047 - 9055
ONCOTARGET., vol. 7, no. 3, 19 January 2016 (2016-01-19), pages 3217 - 32
BLOOD, vol. 124, no. 7, 14 August 2014 (2014-08-14), pages 1127 - 1135
NAGASAWA, H. ET AL., ORG. BIOMOL. CHEM., vol. 14, 2016, pages 2090
"Molecular Design", vol. 7, 1990, HIROKAWA SHOTEN CO., article "Pharmaceutical research and development", pages: 163 - 198
KOHN, H. ET AL., J. MED. CHEM., vol. 54, 2011, pages 4815
KUNZ, H.FRIEDRICH-BOCHNITSCHEK, S., J. ORG. CHEM., vol. 54, 1989, pages 751
See also references of EP 3747894A4
HATTORI KOZO ET AL.: "Solution-Phase Synthesis and Biological Evaluation of Triostin A and its Analogues", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 14, no. 6, 2016, pages 2090 - 2111, XP055630686
CANCER CHEMOTHER. PHARMACOL., vol. 34, 1994, pages 266 - 269
CANCER RES., vol. 19, 2005, pages 99047 - 9055
ONCOTARGET., vol. 7, no. 3, 19 January 2016 (2016-01-19), pages 3217 - 32
BLOOD, vol. 124, no. 7, 14 August 2014 (2014-08-14), pages 1127 - 1135
NAGASAWA, H. ET AL., ORG. BIOMOL. CHEM., vol. 14, 2016, pages 2090
"Molecular Design", vol. 7, 1990, HIROKAWA SHOTEN CO., article "Pharmaceutical research and development", pages: 163 - 198
KOHN, H. ET AL., J. MED. CHEM., vol. 54, 2011, pages 4815
KUNZ, H.FRIEDRICH-BOCHNITSCHEK, S., J. ORG. CHEM., vol. 54, 1989, pages 751
See also references of EP 3747894A4
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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