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Title:
CROSSLINKED NUCLEOSIDE INTERMEDIATE CRYSTAL AND METHOD FOR PRODUCING SAME, AND METHOD FOR PRODUCING CROSSLINKED NUCLEOSIDE AMIDITE
Document Type and Number:
WIPO Patent Application WO/2020/256084
Kind Code:
A1
Abstract:
A crystal of a compound represented by formula 5. In formula 5, R1 represents a hydroxyl protecting group, and R2 represents a leaving group.

Inventors:
KOHGO SATORU (JP)
Application Number:
PCT/JP2020/024037
Publication Date:
December 24, 2020
Filing Date:
June 18, 2020
Export Citation:
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Assignee:
YAMASA CORP (JP)
International Classes:
C07H19/067; C07H15/18; C07H19/10; C07H19/167; C07H19/20
Foreign References:
JP2002521310A2002-07-16
JPH10304889A1998-11-17
Other References:
FUKUYAMA, KEI: "Development of Efficient Synthetic Methods for C4- Tetrasubstituted Nucleoside Derivatives with Pharmacological Activities", TOHOKU UNIVERSITY DOCTORAL DISSERTATION, 25 March 2016 (2016-03-25), pages 1 - 102, XP055773874, Retrieved from the Internet
KOSHIKIN, ALEXEI A. ET AL.: "A Simplified and Efficient Route to 2'-0, 4'- C-Methylene-Linked Bicyclic Ribonucleosides (Locked Nucleic Acid", J. ORG. CHEM., vol. 66, 2001, pages 8504 - 8512, XP055319074, DOI: 10.1021/jo010732p
KOSHIKIN, ALEXEI A. ET AL.: "LNA (Locked Nucleic Acids): Synthesis of the Adenine, Cytosine, Guanine, 5-Methylcytosine, Thymine and Uracil Bicyclonucleoside Monomers", OLIGOMERISATION, AND UNPRECEDENTED NUCLEIC ACID RECOGNITION, TETRAHEDRON, vol. 54, 1998, pages 3607 - 3630, XP002268966, DOI: 10.1016/S0040-4020(98)00094-5
WAGA, YOSHIAKI ET AL.: "Studies on sugar-modified nucleosides", PART I. SYNTHESIS OF 4'-C- METHYLNUCLEOSIDES , BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, vol. 57, no. 9, 1993, pages 1433 - 1438, XP000917028
Attorney, Agent or Firm:
AXIS PATENT INTERNATIONAL (JP)
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