Title:
CRYSTAL FORM OF COAGULATION FACTOR XIA INHIBITOR AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/259366
Kind Code:
A1
Abstract:
Disclosed are a crystal form of a coagulation factor XIa inhibitor and a preparation method therefor, wherein the X-ray powder diffraction pattern of the crystal form comprises diffraction peaks of the 2θ angle at 6.9±0.2°, 15.9±0.2°, 21.8±0.2°, 23.7±0.2° and 28.2±0.2°. The crystal form has a better performance, a high stability, and can be used to prepare medical agents for treating cardiovascular diseases.
Inventors:
ZHANG JIE (CN)
DONG JICHUAN (CN)
HUANG HE (CN)
LEI XIN (CN)
CHEN YONG (CN)
WANG ZHONGQING (CN)
LUO ZHONGHUA (CN)
HUANG FANGFANG (CN)
DONG JICHUAN (CN)
HUANG HE (CN)
LEI XIN (CN)
CHEN YONG (CN)
WANG ZHONGQING (CN)
LUO ZHONGHUA (CN)
HUANG FANGFANG (CN)
Application Number:
PCT/CN2020/096572
Publication Date:
December 30, 2020
Filing Date:
June 17, 2020
Export Citation:
Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07D205/08; A61K31/397; A61K31/4025; A61P7/02
Foreign References:
| US20040180855A1 | 2004-09-16 | |||
| JP2005095167A | 2005-04-14 | |||
| CN1202081C | 2005-05-18 |
Other References:
SUTTON JAMES C, BOLTON SCOTT A, HARTL KAREN S, HUANG MING-HSING, JACOBS GLENN, MENG WEI, OGLETREE MARTIN L, PI ZULAN, SCHUMACHER W: "Synthesis and SAR of 4-Carboxy-2-azetidinone Mechanism-Based Tryptase Inhibitors.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, no. 21, 4 November 2002 (2002-11-04), pages 3229 - 3233, XP055774047, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(02)00688-1
SUTTON JAMES C; BOLTON SCOTT A; DAVIS MALCOLM E; HARTL KAREN S; JACOBSON BRUCE; MATHUR ARVIND; OGLETREE MARTIN L; SLUSARCHYK WILLI: "Solid-phase Synthesis and SAR of 4-carboxy-2-azetidinone Mechanism-based Tryptase Inhibitors.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 9, 3 May 2004 (2004-05-03), pages 2233 - 2239, XP085050325, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2004.02.012
XINHUA QIAN, BIN ZHENG, BRIAN BURKE, MANOHAR T. SAINDANE, AND DAVID R. KRONENTHAL: "A Stereoselective Synthesis of BMS-262084, an Azetidinone-Based Tryptase Inhibitor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 67, no. 11, 27 April 2002 (2002-04-27), pages 3595 - 3600, XP055774051, ISSN: 0022-3263, DOI: 10.1021/jo010757o
SUTTON JAMES C; BOLTON SCOTT A; DAVIS MALCOLM E; HARTL KAREN S; JACOBSON BRUCE; MATHUR ARVIND; OGLETREE MARTIN L; SLUSARCHYK WILLI: "Solid-phase Synthesis and SAR of 4-carboxy-2-azetidinone Mechanism-based Tryptase Inhibitors.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 9, 3 May 2004 (2004-05-03), pages 2233 - 2239, XP085050325, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2004.02.012
XINHUA QIAN, BIN ZHENG, BRIAN BURKE, MANOHAR T. SAINDANE, AND DAVID R. KRONENTHAL: "A Stereoselective Synthesis of BMS-262084, an Azetidinone-Based Tryptase Inhibitor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 67, no. 11, 27 April 2002 (2002-04-27), pages 3595 - 3600, XP055774051, ISSN: 0022-3263, DOI: 10.1021/jo010757o
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