Title:
CRYSTAL FORM E OF BULLEYACONITINE A, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/186962
Kind Code:
A1
Abstract:
Provided is a crystal form E of bulleyaconitine A and a preparation method for the crystal form E of bulleyaconitine A. An X-ray powder diffraction spectrum of the crystal form measured by Cu-K α-ray is as shown in FIG. 1. The crystal form E of bulleyaconitine A is prepared by adding a mixed solution of alcohol and water to bulleyaconitine A, stirring to obtain a suspended solid, and centrifugally collecting the solid. The alcohol is methanol, ethanol or n-butanol. The preparation process is simple, and the obtained crystal form has high purity and is characterized by XRD, DSC, TGA, and 1HNMR to be determined as the crystal form E. The obtained bulleyaconitine A crystal is an anhydrous crystal form, and stability test results show that the crystal has good light, humidity and heat stability.
Inventors:
WU QIONGFEN (CN)
LI BIAO (CN)
LI BIAO (CN)
Application Number:
PCT/CN2020/076156
Publication Date:
September 24, 2020
Filing Date:
February 21, 2020
Export Citation:
Assignee:
YUNNAN HAOPY PHARMACEUTICALS LTD (CN)
International Classes:
C07D221/22; A61P25/04; A61P29/00
Foreign References:
| CN109824595A | 2019-05-31 | |||
| CN101555227A | 2009-10-14 | |||
| CN102924376A | 2013-02-13 | |||
| CN106008344A | 2016-10-12 | |||
| CN104326981A | 2015-02-04 | |||
| CN101830849A | 2010-09-15 |
Other References:
YUAN, MEI ET AL.: "Non-official: Chemical Constituents of Aconitum Bulleyanum", JOURNAL OF CHINESE MEDICINAL MATERIALS, vol. 36, no. 6, 30 June 2013 (2013-06-30), pages 938 - 940, DOI: 20200314115249X
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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