Title:
CRYSTAL FORM OF FATTY ACID BILE ACID CONJUGATE, METHOD FOR PREPARING SAME, AND APPLICATION
Document Type and Number:
WIPO Patent Application WO/2018/223836
Kind Code:
A1
Abstract:
The present invention relates to a novel crystal form of a compound (I), a method for preparing same, and an application. Crystal form CS3, crystal form CS2, crystal form CS5, and crystal form CS8 of the compound (I) provided by the present invention have advantages in at least one of the aspects of solubility, stability, melting point, hygroscopicity, particle size, bioavailability, processability, purification, fluidity, adhesiveness, stability in a preparation, and in vitro dissolution, provide a new and better option for preparation of a pharmaceutical preparation containing the compound (I), and are of great significance for pharmaceutical development.
Inventors:
CHEN MINHUA (CN)
ZHANG YANFENG (CN)
HUANG CHUNXIANG (CN)
ZHANG XIAOYU (CN)
ZHANG YANFENG (CN)
HUANG CHUNXIANG (CN)
ZHANG XIAOYU (CN)
Application Number:
PCT/CN2018/087680
Publication Date:
December 13, 2018
Filing Date:
May 21, 2018
Export Citation:
Assignee:
CRYSTAL PHARMACEUTICAL SUZHOU CO LTD (CN)
International Classes:
C07J41/00; A61K31/575; A61P1/04; C07C229/26; C07J9/00
Foreign References:
| CN105848718A | 2016-08-10 | |||
| CN1296492A | 2001-05-23 | |||
| CN100386339C | 2008-05-07 |
Other References:
See also references of EP 3636655A4
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