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Title:
CRYSTAL OF M RECEPTOR ANTAGONIST AS WELL AS PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/218833
Kind Code:
A1
Abstract:
The main purpose of the present invention is to provide a novel crystal of a quaternary ammonium salt structure compound, i.e., (2R,3R)-3-[(2-cyclopentyl-2-hydroxy-2-phenyl)ethoxy]-1-(3-phenoxypropyl)-1-azabicyclo[2,2,2]octylonium bromide (hereinafter referred to as compound I). A type A crystal of compound I displays diffraction peaks at the following diffraction angles 2θ in a powder X-ray diffraction pattern thereof: 5.7±0.2 degrees, 12.9±0.2 degrees, 16.7±0.2 degrees, 18.0±0.2 degrees, 19.5±0.2 degrees, 21.1±0.2 degrees, 22.3±0.2 degrees and 23.3±0.2 degrees. A type B crystal of compound I displays diffraction peaks at the following diffraction angles 2θ in a powder X-ray diffraction pattern thereof: 5.2±0.2 degrees, 15.8±0.2 degrees, 16.9±0.2 degrees, 17.7±0.2 degrees, 19.5±0.2 degrees, 20.2±0.2 degrees and 22.1±0.2 degrees. The present invention also relates to a new preparation method for compound I and an application of the two novel crystals in the field of medicine.

Inventors:
CHEN XIAOPING (CN)
GAO ZEJUN (CN)
Application Number:
PCT/CN2021/089464
Publication Date:
November 04, 2021
Filing Date:
April 24, 2021
Export Citation:
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Assignee:
BEIJING SHOWBY PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D453/02; A61K31/49; A61P1/00; A61P11/00; A61P11/02; A61P11/06; A61P11/14; A61P13/10
Domestic Patent References:
WO2015007073A12015-01-22
WO2018108089A12018-06-21
Foreign References:
CN102850345A2013-01-02
US6380388B12002-04-30
CN101830896A2010-09-15
CN1976701A2007-06-06
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