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Title:
CRYSTAL POLYMORPH OF 8-BROMO-2-(1-METHYLPIPERIDIN-4-YLAMINO)-4-(4-PHENOXYPHENYLAMINO)PYRIDO[4,3-D]PYRIMIDIN-5(6H)-ONE HYDROCHLORIDE AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2020/040467
Kind Code:
A1
Abstract:
An embodiment relates to a crystal polymorph of 8-bromo-2-(1-methylpiperidin-4-ylamino)-4-(4-phenoxyphenylamino)pyrido[4,3-d]pyrimidin-5(6H)-one hydrochloride which can effectively suppress FLT3 and has excellent stability even in a high temperature and humid environment, and a method for preparing same.

Inventors:
KIM JUNG-HO (KR)
CHOI JANG-SIK (KR)
LEE HEE KYU (KR)
PARK SONG-EUN (KR)
JUNG DONG-SIK (KR)
CHOI YUNG-GEUN (KR)
KOH JONG-SUNG (KR)
KIM SE-WON (KR)
LEE JAEKYOO (KR)
Application Number:
PCT/KR2019/010210
Publication Date:
February 27, 2020
Filing Date:
August 12, 2019
Export Citation:
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Assignee:
OSCOTEC INC (KR)
International Classes:
C07D487/04
Foreign References:
KR20140144709A2014-12-19
KR20120140643A2012-12-31
KR100774271B12007-11-08
KR20070083471A2007-08-24
KR20140144709A2014-12-19
Other References:
MUDALIP, ABDUL S. K. ET AL.: "Effects of Solvents on Polymorphism and Shape of Mefenamic Acid Crystals", MALAYSIA TECHNICAL UNIVERSITIES CONFERENCE ON ENGINEERING AND TECHNOLOGY (MUCET 2017) - MATEC WEB OF CONFERENCES, vol. 150, 23 February 2018 (2018-02-23), pages 1 - 6, XP055688830
See also references of EP 3842434A4
Attorney, Agent or Firm:
FIRSTLAW P.C. (KR)
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