CYANINE COMPOUND AND FLUORESCENT DYE USING SAME

WIPO Patent Application WO/2019/012963

A1

Fluorescent dyes for use in live-cell DNA imaging are required to have sufficient cell-penetrating properties, excellent DNA/RNA selectivity, and an absorption band corresponding to a long wavelength laser which is less likely to cause phototoxicity. However, no molecular group which resolves these three challenges has been developed. The challenges can be resolved by cyanine compounds represented by general formula (1), the compounds being a group of molecules that are effective for live-cell DNA imaging. In general formula (1), R1 and R2 are the same or different and represent a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group, R3, R4, R5 and R6 are the same or different and represent a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, or a substituted or unsubstituted amino group, and R7, R8, R9 and R10 are the same or different and represent a hydrogen atom, a substituted or unsubstituted alkyl group, or a substituted or unsubstituted alkoxy group, X1d represents a hydrogen atom or a halogen atom, Y represents a monovalent anion, n is 0 or 1, and when X1 is a halogen atom, n is 0.

SATO YOSHIKATSU (JP)
UNO KAKISHI (JP)

PCT/JP2018/023877

January 17, 2019

June 22, 2018

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UNIV NAGOYA NAT UNIV CORP (JP)

C09B23/00; C12Q1/6823; G01N21/64

JPH0550758A	1993-03-02
JPH05142810A	1993-06-11
US20040047806A1	2004-03-11

J ACQUES, METZGER: "Behavior and reactivity of heterocycloammonium compounds in the synthesis of cyanine and carbocyanine dyes. X. Structures and properties of asymmetric anhydro bases containing a pyridine ring", BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE, 1969, pages 1275 - 1283

SAEGUSA & PARTNERS (JP)

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