A compound of formula I

(I)

wherein

X is O or S;

X¹, X², X³ and X⁴ are each independently O or NH;

R¹ and R² are independently

Z¹ is N or CR^a;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or Ci-₃ alkyl;

R³ is H, CH3, halogen, NH₂ or OH;

R ^a is H, CH3, halogen, NH₂ or OH; or R³ and R ^a may be taken together to form a 3-4 membered carbocycle; or

R³ and R ^a may be taken together to form a C=CH2 substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁹ is H, halogen or methyl;

Y is CR⁵ or N;

m is 0, 1 , 2 or 3;

n is 0 or 1 ;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

2. The compound according to claim 1 of formula I

(I)

wherein

X is S;

X¹, X², X³ and X⁴ are each independently O or NH; R¹ and ² are independently

Z¹ is N or CR^a;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C: 3-6 cycloalkyl substituted with 0-6 R⁵, CN, NC , OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or C 1-3 alkyl;

R³ is H, CH3, halogen, NH₂ or OH;

R ^a is H, CH3, halogen, NH₂ or OH; or

R³ and R ^a may be taken together to form a 3-4 membered carbocycle; or

R³ and R ^a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al; R⁸ is H, halogen, C1-3 alkyl, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁹ is H, halogen or methyl;

Y is CR⁵ or N;

m is 0, 1 , 2 or 3;

n is 0 or 1 ;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

3. The compound according to claim 1 of formula I

(I)

wherein

X is O:

X¹, X², X³ and X⁴ are each independently O or NH;

R¹ and R² are independently

Z¹ is N or CR^a;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or Ci-₃ alkyl;

R³ is H, CH₃, halogen, NH₂ or OH;

R ^a is H, CH₃, halogen, NH₂ or OH; or

R³ and R ^a may be taken together to form a 3-4 membered carbocycle; or

R³ and R ^a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -

NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁹ is H, halogen or methyl;

Y is CR⁵ or N;

m is 0, 1 , 2 or 3;

n is 0 or 1 ;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

4. The compound according to claim 1 of the formula wherein

X¹, X², X³ and X⁴ are each independently O or NH;

R¹ and ² are independently

Z¹ is N or CR^a;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or Ci-₃ alkyl;

R³ is H, CH₃, halogen, NH₂ or OH;

R ^a is H, CH₃, halogen, NH₂ or OH; or

R³ and R ^a may be taken together to form a 3-4 membered carbocycle; or

R³ and R ^a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5ais H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -

NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁹ is H, halogen or methyl;

Y is CR⁵ or N;

m is 0, 1, 2 or 3;

n is O or l;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

5. The compound according to claim 1 of the formula

wherein

X¹, X², X³ and X⁴ are each independently O or NH;

R¹ and R² are independently

Z¹ is N or CR^a;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C: 3-6 cycloalkyl substituted with 0-6 R⁵, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or Ci-₃ alkyl;

R³ is H, CH3, halogen, NH₂ or OH;

R ^a is H, CH3, halogen, NH₂ or OH; or

R³ and R ^a may be taken together to form a 3-4 membered carbocycle; or

R³ and R ^a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁹ is H, halogen or methyl;

Y is CR⁵ or N;

m is 0, 1, 2 or 3;

n is 0 or 1;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

6. The compound according to claim 1 of the formula

X is O or S;

1 and R² are independently

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al; R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or C 1-3 alkyl;

R³ is H, CH3, halogen, NH2 or OH;

R ^a is H, CH₃, halogen, NH₂ or OH; or

R³ and R ^a may be taken together to form a 3-4 membered carbocycle; or

R³ and R ^a may be taken together to form a C=CH2 substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁹ is H, halogen or methyl;

Y is CR⁵ or N;

m is 0, 1 , 2 or 3;

n is 0 or 1 ;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

7. The compound according to claim 1 of the formula

wherein

X is O or S;

1 and R² are independently

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or C 1-3 alkyl;

R³ is F;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁹ is H, halogen or methyl;

Y is CR⁵ or N;

m is 0, 1, 2 or 3;

n is 0 or 1 ;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

The compound according to claim 1 of the formula

wherein

X is O or S;

X¹, X², X³ and X⁴ are each independently O or NH;

1 and R² are independently

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or Ci-₃ alkyl;

R³ is H, CH₃, halogen, NH₂ or OH;

R ^a is H, CH₃, halogen, NH₂ or OH; or

R³ and R ^a may be taken together to form a 3-4 membered carbocycle; or

R³ and R ^a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -

NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

Y is CR⁵ or N;

m is 0, 1 , 2 or 3;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

9. The compound according to claim 1 of the formula

wherein

X is S;

X¹, X², X³ and X⁴ are each independently O or NH;

R¹ and ² are independently

Z¹ is N or CR^a;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or C 1-3 alkyl;

R³ is H, CH3, halogen, NH₂ or OH;

R ^a is H, CH3, halogen, NH₂ or OH; or

R³ and R ^a may be taken together to form a 3-4 membered carbocycle; or

R³ and R ^a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl; R⁶ is H, halogen, C1-3 alkyl, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

Y is CR⁵ or N;

m is 0, 1 , 2 or 3;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

10. The compound according to claim 1 of the formula

wherein

X is O;

X¹, X², X³ and X⁴ are each independently O or NH;

1 and R² are independently

Z¹ is N or CR^a; Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or C 1-3 alkyl;

R³ is H, CH3, halogen, NH₂ or OH;

R^3a is H, CH3, halogen, NH₂ or OH; or

R³ and R ^a may be taken together to form a 3-4 membered carbocycle; or

R³ and R ^a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

Y is CR⁵ or N;

m is 0, 1 , 2 or 3;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

11. The compound according to claim 1 of the formula wherein

X¹, X², X³ and X⁴ are each independently O or NH;

R¹ and ² are each independently

Z¹ is N or CR^a;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or Ci-₃ alkyl;

R³ is H, CH₃, halogen, NH₂ or OH;

R ^a is H, CH₃, halogen, NH₂ or OH; or

R³ and R ^a may be taken together to form a 3-4 membered carbocycle; or

R³ and R ^a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5ais H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -

NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

Y is CR⁵ or N;

m is 0, 1, 2 or 3;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

12. The compound according to claim 1 of the formula

wherein

X¹, X², X³ and X⁴ are each independently O or NH;

R¹ and R² are each independently

Z¹ is N or CR^a;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C: 3-6 cycloalkyl substituted with 0-6 R⁵, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or Ci-₃ alkyl;

R³ is H, CH3, halogen, NH₂ or OH;

R ^a is H, CH3, halogen, NH₂ or OH; or

R³ and R ^a may be taken together to form a 3-4 membered carbocycle; or

R³ and R ^a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

Y is CR⁵ or N;

m is 0, 1, 2 or 3;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

13. The compound according to claim 1 of the formula

wherein

X is O or S;

1 and R² are each independently

Z s N or CR³;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al; R^al is H or C 1-3 alkyl;

R³ is H, CH₃, halogen, NH₂ or OH;

R ^a is H, CH₃, halogen, NH₂ or OH; or

R³ and R ^a may be taken together to form a 3-4 membered carbocycle; or

R³ and R ^a may be taken together to form a C=CH2 substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5ais H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

Y is CR⁵ or N;

m is 0, 1, 2 or 3;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

14. The compound according to claim 1 of the formula

wherein

X is S;

R¹ and R² are each independently

Z¹ is N or CR^a;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C: 3-6 cycloalkyl substituted with 0-6 R⁵, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or Ci-₃ alkyl;

R³ is H, CH3, halogen, NH₂ or OH;

R ^a is H, CH3, halogen, NH₂ or OH; or

R³ and R ^a may be taken together to form a 3-4 membered carbocycle; or

R³ and R ^a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

Y is CR⁵ or N;

m is 0, 1, 2 or 3;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

15. The compound according to claim 1 of the formula

wherein

X is O;

1 and R² are each independently

Z s N or CR³;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al; R^al is H or C 1-3 alkyl;

R³ is H, CH₃, halogen, NH₂ or OH;

R ^a is H, CH₃, halogen, NH₂ or OH; or

R³ and R ^a may be taken together to form a 3-4 membered carbocycle; or

R³ and R ^a may be taken together to form a C=CH2 substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5ais H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

Y is CR⁵ or N;

m is 0, 1, 2 or 3;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

16. The compound according to claim 1 of the formula

wherein

R¹ and R² are each independently

Z¹ is N or CR^a;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C: 3-6 cycloalkyl substituted with 0-6 R⁵, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or Ci-₃ alkyl;

R³ is H, CH3, halogen, NH₂ or OH;

R ^a is H, CH3, halogen, NH₂ or OH; or

R³ and R ^a may be taken together to form a 3-4 membered carbocycle; or

R³ and R ^a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

Y is CR⁵ or N;

m is 0, 1, 2 or 3;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

17. The compound according to claim 1 of the formula

wherein

R¹ and R² are each independently

Z¹ is N or CR^a;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵,

-C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or C 1-3 alkyl; R³ is H, CH₃, halogen, NH₂ or OH;

R ^a is H, CH₃, halogen, NH₂ or OH; or

R³ and R ^a may be taken together to form a 3-4 membered carbocycle; or

R³ and R ^a may be taken together to form a C=CH2 substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5ais H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

Y is CR⁵ or N;

m is 0, 1, 2 or 3;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

18. The com ound according to claim 1 of the formula

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

The compound according to claim 1 of the formula

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

20. A compound of formula II (Π) wherein

X is O or S;

X¹, X², X³ and X⁴ are each independently O

1 and R² are each independently

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or C 1-3 alkyl;

R⁴ is H, CH3, halogen, NH₂ or OH;

R^4a is H, CH3, halogen, NH₂ or OH; or

R⁴ and R^4a may be taken together to form a 3-4 membered carbocycle; or

R⁴ and R^4a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl; R⁶ is H, halogen, C1-3 alkyl, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁹ is H, halogen or methyl;

Y is CR⁵ or N;

m is 0, 1 , 2 or 3;

n is 0 or 1 ;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

21. The compound according to claim 20 of formula II

wherein

X is S;

X¹, X², X³ and X⁴ are each independently O or NH;

R¹ and R² are each independently

Z¹ is N or CR^a;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C: 3-6 cycloalkyl substituted with 0-6 R⁵, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or Ci-₃ alkyl;

R⁴ is H, CH3, halogen, NH₂ or OH;

R^4a is H, CH3, halogen, NH₂ or OH; or

R⁴ and R^4a may be taken together to form a 3-4 membered carbocycle; or

R⁴ and R^4a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, S(0)₂R^al or S(0)₂NR^alR^al;

R⁹ is H, halogen or methyl;

Y is CR⁵ or N;

m is 0, 1, 2 or 3;

n is 0 or 1;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

22. The compound according to claim 20 of formula II

(II)

wherein

X is O;

X¹, X², X³ and X⁴ are each independently O or NH;

R¹ and R² are each independently

Z¹ is N or CR^a;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al; R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or C 1-3 alkyl;

R⁴ is H, CH3, halogen, NH2 or OH;

R^4a is H, CH₃, halogen, NH₂ or OH; or

R⁴ and R^4a may be taken together to form a 3-4 membered carbocycle; or

R⁴ and R^4a may be taken together to form a C=CH2 substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁹ is H, halogen or methyl;

Y is CR⁵ or N;

m is 0, 1 , 2 or 3;

n is 0 or 1 ;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

23. The compound according to claim 20 of the formula

wherein

X¹, X², X³ and X⁴ are each independently O or NH;

R¹ and ² are each independently

Z¹ is N or CR^a;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, -

NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or C 1-3 alkyl;

R⁴ is H, CH3, halogen, NH₂ or OH;

R^4a is H, CH3, halogen, NH₂ or OH; or

R⁴ and R^4a may be taken together to form a 3-4 membered carbocycle; or

R⁴ and R^4a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -

NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5ais H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁹ is H, halogen or methyl;

Y is CR⁵ or N;

m is 0, 1 , 2 or 3;

n is 0 or 1 ;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

24. The compound according to claim 20 of the formula

wherein

X¹, X², X³ and X⁴ are each independently O or NH;

R¹ and ² are each independently

Z¹ is N or CR^a;

Z² is NR^b; R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)2R^al, -NR^alS(0)2NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)2R^al or S(0)2NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵,

-C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or C 1-3 alkyl;

R⁴ is H, CH3, halogen, NH2 or OH;

R^4a is H, CH3, halogen, NH2 or OH; or

R⁴ and R^4a may be taken together to form a 3-4 membered carbocycle; or

R⁴ and R^4a may be taken together to form a C=CH2 substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)2R^al, -NR^alS(0)2NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁹ is H, halogen or methyl;

Y is CR⁵ or N;

m is 0, 1 , 2 or 3;

n is 0 or 1 ;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

25. The compound according to claim 20 of the formula

X is O or S;

1 and R² are each independently

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or Ci-₃ alkyl;

R⁴ is H, CH3, halogen, NH₂ or OH;

R^4a is H, CH3, halogen, NH₂ or OH; or

R⁴ and R^4a may be taken together to form a 3-4 membered carbocycle; or

R⁴ and R^4a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5ais H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -

NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁹ is H, halogen or methyl;

Y is CR⁵ or N;

m is 0, 1, 2 or 3;

n is O or l;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

26. The compound according to claim 20 of the formula

wherein

X is O or S;

X¹, X², X³ and X⁴ are each independently O or NH;

R¹ and R² are each independently

Z¹ is N or CR^a;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C: 3-6 cycloalkyl substituted with 0-6 R⁵, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or Ci-₃ alkyl;

R⁴ is F;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁹ is H, halogen or methyl; Y is CR⁵ or N;

m is 0, 1, 2 or 3;

n is 0 or 1 ;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

27. The compound according to claim 20 of the formula

wherein

X is O or S;

X¹, X², X³ and X⁴ are each independently O or NH;

R¹ and R² are each independently

Z s N or CR³;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)2R^al, -NR^alS(0)2NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)2R^al or S(0)2NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al; R^al is H or C 1-3 alkyl;

R⁴ is H, CH₃, halogen, NH₂ or OH;

R^4a is H, CH₃, halogen, NH₂ or OH; or

R^4a is H, CH₃, halogen or OH; or

R⁴ and R^4a may be taken together to form a 3-4 membered carbocycle; or

R⁴ and R^4a may be taken together to form a C=CH2 substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5ais H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

Y is CR⁵ or N;

m is 0, 1, 2 or 3;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

28. The compound according to claim 20 of the formula

wherein X is S;

X¹, X², X³ and X⁴ are each independently O or NH;

1 and R² are each independently

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or C 1-3 alkyl;

R⁴ is H, CH3, halogen, NH₂ or OH;

R^4a is H, CH3, halogen, NH₂ or OH; or

R⁴ and R^4a may be taken together to form a 3-4 membered carbocycle; or

R⁴ and R^4a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

Y is CR⁵ or N;

m is 0, 1 , 2 or 3;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

29. The compound according to claim 20 of the formula

wherein

X is O;

X¹, X², X³ and X⁴ are each independently O or NH;

R¹ and ² are each independently

Z¹ is N or CR^a;

Z² is NR^b; R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)2R^al, -NR^alS(0)2NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)2R^al or S(0)2NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵,

-C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or C 1-3 alkyl;

R⁴ is H, CH3, halogen, NH2 or OH;

R^4a is H, CH3, halogen, NH2 or OH; or

R⁴ and R^4a may be taken together to form a 3-4 membered carbocycle; or

R⁴ and R^4a may be taken together to form a C=CH2 substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)2R^al, -NR^alS(0)2NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

Y is CR⁵ or N;

m is 0, 1 , 2 or 3;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

30. The compound according to claim 20 of the formula wherein

X¹, X², X³ and X⁴ are each independently O or NH;

1 and R² are each independently

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or Ci-₃ alkyl;

R⁴ is H, CH₃, halogen, NH₂ or OH;

R^4a is H, CH₃, halogen, NH₂ or OH; or

R⁴ and R^4a may be taken together to form a 3-4 membered carbocycle; or

R⁴ and R^4a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5ais H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -

NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

Y is CR⁵ or N;

m is 0, 1, 2 or 3;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

31. The compound according to claim 20 of the formula

wherein

X¹, X², X³ and X⁴ are each independently O or NH;

R¹ and ² are each independently

Z¹ is N or CR^a;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, -

NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or C 1-3 alkyl;

R⁴ is H, CH3, halogen, NH₂ or OH;

R^4a is H, CH3, halogen, NH₂ or OH; or

R⁴ and R^4a may be taken together to form a 3-4 membered carbocycle; or

R⁴ and R^4a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -

NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -

NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

Y is CR⁵ or N;

m is 0, 1 , 2 or 3;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

32. The compound according to claim 20 of the formula

X is O or S;

1 and R² are each independently

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or Ci-₃ alkyl;

R⁴ is H, CH3, halogen, NH₂ or OH;

R^4a is H, CH3, halogen, NH₂ or OH; or

R⁴ and R^4a may be taken together to form a 3-4 membered carbocycle; or

R⁴ and R^4a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -

OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5ais H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -

NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

Y is CR⁵ or N;

m is 0, 1, 2 or 3;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

33. The compound according to claim 20 of the formula

wherein

X is S;

R¹ and ² are each independently

Z¹ is N or CR^a;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, -

NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or C 1-3 alkyl;

R⁴ is H, CH3, halogen, NH₂ or OH;

R^4a is H, CH3, halogen, NH₂ or OH; or

R⁴ and R^4a may be taken together to form a 3-4 membered carbocycle; or

R⁴ and R^4a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -

NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -

NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

Y is CR⁵ or N;

m is 0, 1 , 2 or 3;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

34. The compound according to claim 20 of the formula

wherein

X is O;

R¹ and R² are each independently

Z¹ is N or CR^a;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, -

NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or C 1-3 alkyl;

R⁴ is H, CH3, halogen, NH₂ or OH;

R^4a is H, CH3, halogen, NH₂ or OH; or

R⁴ and R^4a may be taken together to form a 3-4 membered carbocycle; or

R⁴ and R^4a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5ais H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -

NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

Y is CR⁵ or N;

m is 0, 1, 2 or 3;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

35. The compound according to claim 20 of the formula

wherein

R¹ and ² are each independently

Z¹ is N or CR^a;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, -

NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or C 1-3 alkyl;

R⁴ is H, CH3, halogen, NH₂ or OH;

R^4a is H, CH3, halogen, NH₂ or OH; or

R⁴ and R^4a may be taken together to form a 3-4 membered carbocycle; or

R⁴ and R^4a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -

NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -

NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

Y is CR⁵ or N;

m is 0, 1 , 2 or 3;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

36. The compound according to claim 20 of the formula wherein

1 and R² are each independently

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, -

NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or C 1-3 alkyl;

R⁴ is H, CH3, halogen, NH₂ or OH;

R^4a is H, CH3, halogen, NH₂ or OH; or

R⁴ and R^4a may be taken together to form a 3-4 membered carbocycle; or

R⁴ and R^4a may be taken together to form a C=CH₂ substituent;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R^5a is H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -

NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

Y is CR⁵ or N;

m is 0, 1, 2 or 3;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

37. The compound according to claim 20 of the formula

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

38. A compound which is

(1 R,6S,8R,9R, 15R, 17R, 18R)-8, 17-bis(6-amino-9H-purin-9-yl)-l 8-fluoro-3, 12- disulfanyl-2,4,l l,13,16-pentaoxa-3 ⁵,12 ⁵-diphosphatricyclo[13.3.0.0⁶'⁹]octadecane-3,12- dione; (1 R,6S,8R,9R, 15R, 17R, 18R)- 17-(6-amino-9H-purin-9-yl)-l 8-fluoro-3, 12- dihydroxy-8-{4-hydroxy-lH-imidazo[2,l-b]purin-l-yl}-2,4,l l,13,16-pentaoxa-3 ⁵,12 ⁵- diphosphatricy clo[ 13.3.0.0⁶·⁹] octadecane-3 , 12-dithione;

(1 R,6S,8R,9R, 15R, 17R, 18R)-8, 17-bis(6-amino-9H-purin-9-yl)-3, 12, 18- trihydroxy-2,4,11,13, 16-pentaoxa-3 ⁵,12 ⁵-diphosphatricyclo[13.2.1.0⁶'⁹]octadecane- 3,12-dithione;

9-[(l R,6S,8R,9R, 15R, 17R, 18R)- 17-(6-amino-9H-purin-9-yl)- 18-fluoro-3, 12- dihy droxy-3, 12-disulfanylidene-2,4, 11,13,16-pentaoxa-3 ⁵, 12λ⁵- diphosphatricyclo[13.3.0.0^{6 9}]octadecan-8-yl]- 6,9-dihydro-lH-purin-6-one;

(1 S,6S,8R,9R, 15R, 17R)-8-(6-amino-9H-purin-9-yl)- 17- {4-chloro-7H-pyrrolo[2,3- d]pyrimidin-7-yl}-3-hydroxy-12-sulfanyl-3-sulfanylidene-2,4,l l,13,16-pentaoxa- 3 ⁵,12 ⁵-diphosphatricyclo[13.3.0.0⁶'⁹]octadecan-12-one;

(1 R,6S,8R,9R, 15R, 17R, 18S)-8-(6-amino-9H-purin-9-yl)-l 7- {4-chloro-7H- pyrrolo[2,3-d]pyrimidin-7-yl}-18-fluoro-3,12-dihydroxy-2,4,l l,13,16-pentaoxa-3 ⁵,12 ⁵- diphosphate cy clo[ 13.3.0.0⁶·⁹] octadecane-3 , 12-dithione;

(1 R,6S,8R,9R, 15R, 17R, 18S)- 17- {4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl} -8- (6-amino-9H-purin-9-y 1)- 18-fluoro-3 , 12-dihy droxy-2,4, 11,13,16-pentaoxa-3 ⁵, 12λ⁵- diphosphatricyclo[13.3.0.0⁶'⁹]octadecane-3,12-dithione

l-[(lR,6S,8R,9R,15R,17R,18R)-8-(6-amino-9H-purin-9-yl)-18-fluoro-3,12- dihy droxy-3, 12-disulfanylidene-2,4, 11,13,16-pentaoxa-3 ⁵, 12λ⁵- diphosphatricyclo[13.3.0.0⁶'⁹]octadecan-17-yl]- lH,4H,5H-imidazo[2,l-b]purin-4-one;

(1 R,6S,8R,9R, 15R, 17R, 18R)-8, 17-bis(6-amino-9H-purin-9-yl)-l 8-fluoro-3, 12- dihydroxy-2,4,11,13, 16-pentaoxa-3 ⁵,12 ⁵-diphosphatricyclo[l 3.3.0.0⁶'⁹]octadecane- 3,12-dione;

1 -[(1 S,6S,8R,9R, 15R, 17R, 18R)-8-(6-amino-9H-purin-9-yl)- 18-fluoro-3, 12- dihy droxy-3, 12-disulfanylidene-2,4, 11,13,16-pentaoxa-3 ⁵, 12λ⁵- diphosphatricyclo[13.2.1.0⁶'⁹]octadecan-17-yl]- lH-l,2,3-benzotriazole-4-carboxamide; l-[(lR,6S,8R,9R,15R,17R,18R)-8-(6-amino-9H-purin-9-yl)-18-fluoro-3,12- dihy droxy-3, 12-disulfanylidene-2,4, 11,13,16-pentaoxa-3 ⁵, 12λ⁵- diphosphatricyclo[13.3.0.0⁶'⁹]octadecan-17-yl]- lH-l,2,3-benzotriazole-4-carboxamide; 1- [(lR,6S,8R,9R,15R,17R,18R)-17-(6-amino-9H-purin-9-yl)-18-fluoro-3,12- dihy droxy-3, 12-disulfanylidene-2,4, 11,13,16-pentaoxa-3 ⁵, 12λ⁵- diphosphatricyclo[13.3.0.0^{6 9}]octadecan-8-yl]- lH-l,2,3-benzotriazole-4-carboxamide;

(lR,6S,8R,9R,15R,17R,18R)-18-hydroxy-8-(6-hydroxy-9H-purin-9-yl)-17-{4- oxo- lH,4H,5H-imidazo[2, 1 -b]purin-l -yl} -3, 12-disulfany 1-2,4, 11,13,16-pentaoxa- 3 ⁵,12 ⁵-diphosphatricyclo[13.2.1.0⁶'⁹]octadecane-3,12-dione;

(1 R,6S,8R,9R, 15R, 17R, 18R)-8-(6-amino-9H-purin-9-yl)-3, 12, 18-trihy droxy- 17- {4-hydroxy-lH-imidazo[2,l-b]purin-l-yl}-2,4,l l,13,16-pentaoxa-3 ⁵,12 ⁵- diphosphatricyclo[13.2.1.0^{6 9}]octadecane-3,12-dithione;

(1 S,6S,8R,9R, 15R, 17R, 18R)-8-(6-amino-9H-purin-9-yl)-3, 12, 18-trihy droxy- 17-

(6-hy droxy-9H-purin-9-y l)-2,4, 11,13,16-pentaoxa-3 ⁵, 12λ⁵- diphosphatricy clo[ 13.3.0.0^{6 9}] octadecane-3 , 12-dithione;

(lR,6S,8R,9R,15R,17R,18S)-8,17-bis(6-amino-9H-purin-9-yl)-18-fluoro-3,12- dihydroxy-2,4,11,13, 16-pentaoxa-3 ⁵,12 ⁵-diphosphatricyclo[l 3.3.0.0⁶'⁹]octadecane- 3,12-dithione; and

2- amino-9-[(lR,6S,8R,9R,15R,17R,18R)-17-(6-amino-9H-purin-9-yl)-18-fluoro- 3,12-dihydroxy-3,12-disulfanylidene-2,4,l l,13,16-pentaoxa-3 ⁵,12 ⁵- diphosphatricyclo[13.3.0.0⁶'⁹]octadecan-8-yl]- 6,9-dihydro-lH-purin-6-one

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

39. The compound according to claim 38 which is

(1 R,6S,8R,9R, 15R, 17R, 18R)-8, 17-bis(6-amino-9H-purin-9-yl)-l 8-fluoro-3, 12- disulfanyl-2,4,l l,13,16-pentaoxa-3 ⁵,12 ⁵-diphosphatricyclo[13.3.0.0⁶'⁹]octadecane-3,12- dione;

(lR,6S,8R,9R,15R,17R,18R)-17-(6-amino-9H-purin-9-yl)-18-fluoro-3,12- dihydroxy-8-{4-hydroxy-lH-imidazo[2,l-b]purin-l-yl}-2,4,l l,13,16-pentaoxa-3 ⁵,12 ⁵- diphosphatricy clo[ 13.3.0.0^{6 9}] octadecane-3 , 12-dithione;

2-ainino-9-[(lR,6S,8R,9R,15R,17R,18R)-17-(6-amino-9H-purin-9-yl)-18-fluoro- 3,12-dihydroxy-3,12-disulfanylidene-2,4,l l,13,16-pentaoxa-3 ⁵,12 ⁵- diphosphate cyclo[l 3.3.0.0⁶'⁹]octadecan-8-yl]- 6,9-dihydro-lH-purin-6-one

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

40. A compound according to claim 1 wherein the compound has an EC50 <100 μΜ in the THP 1 IRF3 Reporter Assay.

41. A compound according to claim 20 wherein the compound has an EC50 <100 μΜ in the THP 1 NFkB Reporter Assay.

42. A pharmaceutical composition comprising a compound according to claim 1 or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable carriers, diluents or excipients.

43. A pharmaceutical composition comprising a compound according to claim 20 or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable carriers, diluents or excipients. 44. A combination pharmaceutical product comprising a compound according to claim 1 or a pharmaceutically acceptable salt thereof taken together with one or more other therapeutically active agents.

45. A combination pharmaceutical product comprising a compound according to claim 20 or a pharmaceutically acceptable salt thereof taken together with one or more other therapeutically active agents.

46. The combination product of claim 44 wherein the agents are taken concurrently or sequentially.

47. The combination product of claim 45 wherein the agents are taken concurrently or sequentially.

48. A compound according to claim 1 or a pharmaceutically acceptable salt thereof for use in the treatment of diseases or conditions that may be alleviated by the induction of an immune response via the STING pathway.

49. A compound according to claim 20 or a pharmaceutically acceptable salt thereof for use in the treatment of diseases or conditions that may be alleviated by the induction of an immune response via the STING pathway.

50. The use of a compound according to claim 1 or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment of diseases and conditions in which the modulation of STING is indicated.

51. The use of a compound according to claim 20 or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment of diseases and conditions in which the modulation of STING is indicated.

52. A method of treating diseases and conditions in which the modulation of STING is indicated in a subject in need thereof which comprises administering a therapeutically effective amount of compound according to claim 1 or a pharmaceutically acceptable salt thereof.

53. A method of treating diseases and conditions in which the modulation of STING is indicated in a subject in need thereof which comprises administering a therapeutically effective amount of compound according to claim 20 or a

pharmaceutically acceptable salt thereof.

54. A method of treating cancer comprising administering a therapeutically effective amount of one or more compounds according to claim 1 or a pharmaceutically acceptable salt thereof.

55. A method of treating cancer comprising administering a therapeutically effective amount of one or more compounds according to claim 20 or a pharmaceutically acceptable salt thereof.

56. The method of claim 54 wherein the cancer is small cell lung cancer, non- small cell lung cancer, colorectal cancer, melanoma, renal cell carcinoma, head and neck cancer, Hodgkin's lymphoma, bladder cancer, esophageal carcinoma, gastric carcinoma, ovarian carcinoma, cervical carcinoma, pancreatic carcinoma, prostate carcinoma, breast cancers, urinary carcinoma, brain tumors such as glioblastoma, non-Hodgkin's lymphoma, acute lymphatic leukemia (ALL), chronic lymphatic leukemia (CLL), acute myeloid leukemia (AML), chronic myeloid leukemia (CML), hepatocellular carcinoma, multiple myeloma, gastrointestinal stromal tumors, mesothelioma, and other solid tumors or other hematological cancers.

57. The method of claim 55 wherein the cancer is small cell lung cancer, non- small cell lung cancer, colorectal cancer, melanoma, renal cell carcinoma, head and neck cancer, Hodgkin's lymphoma, bladder cancer, esophageal carcinoma, gastric carcinoma, ovarian carcinoma, cervical carcinoma, pancreatic carcinoma, prostate carcinoma, breast cancers, urinary carcinoma, brain tumors such as glioblastoma, non-Hodgkin's lymphoma, acute lymphatic leukemia (ALL), chronic lymphatic leukemia (CLL), acute myeloid leukemia (AML), chronic myeloid leukemia (CML), hepatocellular carcinoma, multiple myeloma, gastrointestinal stromal tumors, mesothelioma, and other solid tumors or other hematological cancers.

58. The method of claim 56 wherein the cancer is small cell lung cancer, non- small cell lung cancer, colorectal cancer, melanoma, renal cell carcinoma, head and neck cancer, Hodgkin's lymphoma or bladder cancer.

59. The method of claim 57 wherein the cancer is small cell lung cancer, non- small cell lung cancer, colorectal cancer, melanoma, renal cell carcinoma, head and neck cancer, Hodgkin's lymphoma or bladder cancer.

60. A method for treating cancer in a subject in need thereof, comprising administering an effective amount of a compound, according to claim 1 , or a

pharmaceutically acceptable salt thereof,

in combination with the administration of a therapeutically effective amount of one or more immuno-oncology agents.

61. A method for treating cancer in a subject in need thereof, comprising administering an effective amount of a compound, according to claim 20, or a pharmaceutically acceptable salt thereof,

in combination with the administration of a therapeutically effective amount of one or more immuno-oncology agents.

62. A method for treating a subject afflicted with cancer comprising administering to the subject a therapeutically effective amount of:

a) a compound according to claim 1, or a pharmaceutically acceptable salt thereof, and

b) an anti-cancer agent which is an antibody or an antigen-binding portion thereof that binds specifically to a Programmed Death- 1 (PD-1) receptor and inhibits PD- 1 activity. 63. A method for treating a subject afflicted with cancer comprising administering to the subject a therapeutically effective amount of:

a) a compound according to claim 20, or a pharmaceutically acceptable salt thereof, and

b) an anti-cancer agent which is an antibody or an antigen-binding portion thereof that binds specifically to a Programmed Death- 1 (PD-1) receptor and inhibits PD-

1 activity.

64. The method of claim 62, wherein the anti-PD-1 antibody is nivolumab or pembrolizumab.

65. The method of claim 63, wherein the anti-PD-1 antibody is nivolumab or pembrolizumab. g

66. The method of claim 64, wherein the anti-PD-1 antibody is nivolumab.

67. The method of claim 65, wherein the anti-PD-1 antibody is nivolumab.

68. A compound of formula III

(III) wherein

X is O or S;

X¹, X², X³ and X⁴ are each independently O or NH;

R¹ and R² are each independently

Z s N or CR³;

Z² is NR^b;

R^a is H, halogen, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, -OC(0)R^al, - OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -NR^alC(0)NR^alR^al, - NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^b is H, Ci-6 alkyl substituted with 0-6 R⁵, C3-6 cycloalkyl substituted with 0-6 R⁵, -C(0)R^al, -C(0)NR^alR^al, -S(0)₂R^al or S(0)₂NR^alR^al;

R^al is H or C 1-3 alkyl;

R⁵ is H, halogen, C1-3 alkyl, CN, N0₂, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, -

NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al; R^5a is H or C 1-3 alkyl;

R⁶ is H, halogen, C1-3 alkyl, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)2R^al, -NR^alS(0)2NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁸ is H, halogen, C1-3 alkyl, CN, NO2, OH, OR^al, SR^al, -C(0)NR^alR^al, -COOR^al, - OC(0)R^al, -OC(0)NR^alR^al, -NR^alR^al, -NR^al C(0)R^al, - NR^alCOOR^al, - NR^alC(0)NR^alR^al, -NR^alS(0)₂R^al, -NR^alS(0)₂NR^alR^al, -S(0)R^al, - S(0)NR^alR^al, - S(0)₂R^al or S(0)₂NR^alR^al;

R⁹ is H, halogen or methyl;

Y is CR⁵ or N;

m is 0, 1 , 2 or 3;

n is 0 or 1 ;

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.