Title:
CYCLIC-DISULFIDE MODIFIED PHOSPHATE BASED OLIGONUCLEOTIDE PRODRUGS
Document Type and Number:
WIPO Patent Application WO/2022/147214
Kind Code:
A3
Abstract:
This invention relates to a compound comprising a structure of formula (I): cyclic disulfide moiety — phosphorus coupling group (I). The cyclic disulfide moiety has the structure of (C-I), (C-II), or (C-III). This invention also relates to an oligonucleotide comprising one or more compounds that comprise the structure of formula (I), wherein at least one phosphorus coupling group contains a nucleoside or oligonucleotide. The invention also relates to a pharmaceutical composition comprising the oligonucleotide described herein and a method of reducing or inhibiting the expression of a target gene by administering to the subject a therapeutically effective amount of the oligonucleotide described herein.
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Inventors:
KEL'IN ALEXANDER V (US)
PIERSON JUSTIN M (US)
NAIR JAYAPRAKASH K (US)
MAIER MARTIN A (US)
BISBE ANNA (US)
TANG CHENG (US)
PIERSON JUSTIN M (US)
NAIR JAYAPRAKASH K (US)
MAIER MARTIN A (US)
BISBE ANNA (US)
TANG CHENG (US)
Application Number:
PCT/US2021/065636
Publication Date:
August 11, 2022
Filing Date:
December 30, 2021
Export Citation:
Assignee:
ALNYLAM PHARMACEUTICALS INC (US)
International Classes:
C07H21/02; C07D339/00; C07D339/04; C07D339/08
Domestic Patent References:
| WO2020154917A1 | 2020-08-06 | |||
| WO2014088920A1 | 2014-06-12 |
Attorney, Agent or Firm:
TOWNES, Jeffrey (US)
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