Title:
CYCLIC PEPTIDE COMPOUND HAVING KRAS INHIBITING ACTION
Document Type and Number:
WIPO Patent Application WO/2021/090855
Kind Code:
A1
Abstract:
The following were discovered: a cyclic peptide compound that interacts with Ras; and an unnatural amino acid that is useful in the production of said cyclic peptide compound. The cyclic peptide compound was also discovered to inhibit bonding between Ras and SOS. The following were additionally discovered: a specific unnatural amino acid included in said cyclic peptide compound; and a manufacturing method therefor.
Inventors:
TANADA MIKIMASA (JP)
TAKANO KOJI (JP)
MATSUO ATSUSHI (JP)
TAMIYA MINORU (JP)
CHIYODA AYA (JP)
ITO TOSHIYA (JP)
IIDA TAKEO (SG)
TAKANO KOJI (JP)
MATSUO ATSUSHI (JP)
TAMIYA MINORU (JP)
CHIYODA AYA (JP)
ITO TOSHIYA (JP)
IIDA TAKEO (SG)
Application Number:
PCT/JP2020/041277
Publication Date:
May 14, 2021
Filing Date:
November 05, 2020
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C07K5/023; A61K38/12; A61P35/00; A61P43/00; C07K5/037
Domestic Patent References:
| WO2013100132A1 | 2013-07-04 | |||
| WO2018225864A1 | 2018-12-13 | |||
| WO2018225851A1 | 2018-12-13 |
Other References:
NAT. REV. DRUG DISCOV., vol. 13, no. ll, November 2014 (2014-11-01), pages 828 - 851
NAT. REV. DRUG DISCOV., vol. 13, no. 12, December 2014 (2014-12-01), pages 928 - 942
NAT. REV. DRUG DISCOV., vol. 15, no. ll, November 2016 (2016-11-01), pages 771 - 785
FUTURE MED. CHEM., vol. 1, 2009, pages 1289 - 1310
CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 13, no. 7, 2013, pages 821 - 836
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 484, 2017, pages 605 - 611
BIOORG. MED. CHEM. LETT., vol. 27, 2017, pages 2757 - 2761
ACS MED. CHEM. LETT., vol. 8, 2017, pages 732 - 736
See also references of EP 4043478A4
NAT. REV. DRUG DISCOV., vol. 13, no. 12, December 2014 (2014-12-01), pages 928 - 942
NAT. REV. DRUG DISCOV., vol. 15, no. ll, November 2016 (2016-11-01), pages 771 - 785
FUTURE MED. CHEM., vol. 1, 2009, pages 1289 - 1310
CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 13, no. 7, 2013, pages 821 - 836
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 484, 2017, pages 605 - 611
BIOORG. MED. CHEM. LETT., vol. 27, 2017, pages 2757 - 2761
ACS MED. CHEM. LETT., vol. 8, 2017, pages 732 - 736
See also references of EP 4043478A4
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
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