Title:
CYCLIC PEPTIDE HAVING CTLA-4 INHIBITORY ACTIVITY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/070696
Kind Code:
A1
Abstract:
The present invention provides a cyclic peptide that has, in a ring, an amino acid sequence represented by formula (I): X1-His-Pro-X4-Leu-X6-X7-X8-Ser-X10-His-Phe (where X1, X4, X6, X7, X8, and X10 each independently represent an arbitrarily defined amino acid) and that has an activity of specifically binding to human CTLA-4.
Inventors:
KOJOH KANEHISA (JP)
TSUIHIJI KUMIKO (JP)
KATOH SHIZUE (JP)
NAKAMURA MIKIKO (JP)
TSUIHIJI KUMIKO (JP)
KATOH SHIZUE (JP)
NAKAMURA MIKIKO (JP)
Application Number:
PCT/JP2020/037100
Publication Date:
April 15, 2021
Filing Date:
September 30, 2020
Export Citation:
Assignee:
GENEFRONTIER CORP (JP)
International Classes:
A61P35/00; A61K38/12; A61P37/04; A61P43/00; C07K5/12
Domestic Patent References:
| WO2017213158A1 | 2017-12-14 | |||
| WO2017217545A1 | 2017-12-21 |
Foreign References:
| JP2016526885A | 2016-09-08 | |||
| JP2009060905A | 2009-03-26 | |||
| US20140051645A1 | 2014-02-20 | |||
| JP2018519255A | 2018-07-19 | |||
| JP2008271903A | 2008-11-13 | |||
| US20120231496A1 | 2012-09-13 | |||
| US20100168380A1 | 2010-07-01 | |||
| US20130316910A1 | 2013-11-28 | |||
| US20150080549A1 | 2015-03-19 | |||
| US20150050269A1 | 2015-02-19 | |||
| JP2019185266A | 2019-10-24 |
Other References:
ZORZI, A. ET AL., CURR. OPIN. CHEM. BIOL., vol. 38, 2017, pages 30 - 35
ROXIN, A.ZHENG, G., FUTURE MED. CHEM., vol. 4, no. 12, 2012, pages 1601 - 1618
DESIMMIE, B. A. ET AL., MOLECULAR THERAPY, vol. 20, no. 11, 2012, pages 2064 - 2075
GUILLEN SCHLIPPE, Y. V. ET AL., J. AM. CHEM. SOC., vol. 134, 2012, pages 10469 - 10477
BASHIRUDDIN, N. K.SUGA, H., CURR. OPIN. CHEM. BIOL., vol. 24, 2015, pages 131 - 138
LEACH, D. R. ET AL., SCIENCE, vol. 271, no. 5256, 1996, pages 1734 - 1736
XOO, NATURE CHEM. BIO., vol. 5, 2009, pages 502
J. AM. CHEM. SOC., vol. 124, 2002, pages 9972
CHEMBIOCHEM, vol. 10, 2009, pages 1469 - 1472
FLATMAN ET AL., J. CHROMATOGR. B, vol. 848, 2007, pages 79 - 87
SHIMIZU ET AL., METHODS, vol. 36, no. 36, 2005, pages 299 - 304
ZHAO ET AL., NAT. BIOTECHNOL., vol. 16, 1998, pages 258 - 261
See also references of EP 4043076A4
ROXIN, A.ZHENG, G., FUTURE MED. CHEM., vol. 4, no. 12, 2012, pages 1601 - 1618
DESIMMIE, B. A. ET AL., MOLECULAR THERAPY, vol. 20, no. 11, 2012, pages 2064 - 2075
GUILLEN SCHLIPPE, Y. V. ET AL., J. AM. CHEM. SOC., vol. 134, 2012, pages 10469 - 10477
BASHIRUDDIN, N. K.SUGA, H., CURR. OPIN. CHEM. BIOL., vol. 24, 2015, pages 131 - 138
LEACH, D. R. ET AL., SCIENCE, vol. 271, no. 5256, 1996, pages 1734 - 1736
XOO, NATURE CHEM. BIO., vol. 5, 2009, pages 502
J. AM. CHEM. SOC., vol. 124, 2002, pages 9972
CHEMBIOCHEM, vol. 10, 2009, pages 1469 - 1472
FLATMAN ET AL., J. CHROMATOGR. B, vol. 848, 2007, pages 79 - 87
SHIMIZU ET AL., METHODS, vol. 36, no. 36, 2005, pages 299 - 304
ZHAO ET AL., NAT. BIOTECHNOL., vol. 16, 1998, pages 258 - 261
See also references of EP 4043076A4
Attorney, Agent or Firm:
KOIKE, Junzo (JP)
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