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Title:
CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA -AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS
Document Type and Number:
WIPO Patent Application WO1998028268
Kind Code:
A3
Abstract:
Disclosed are compounds which inhibit beta -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Inventors:
WU JING (US)
TUNG JAY S (US)
THORSETT EUGENE D (US)
PLEISS MICHAEL A (US)
NISSEN JEFFREY S (US)
NEITZ JEFFREY (US)
LATIMER LEE H (US)
JOHN VARGHESE (US)
FREEDMAN STEPHEN (US)
BRITTON THOMAS C (US)
AUDIA JAMES E (US)
REEL JON K (US)
MABRY THOMAS E (US)
DRESSMAN BRUCE A (US)
CWI CYNTHIA L (US)
DROSTE JAMES J (US)
HENRY STEVEN S (US)
MCDANIEL STACEY L (US)
SCOTT WILLIAM LEONARD (US)
STUCKY RUSSELL D (US)
PORTER WARREN J (US)
Application Number:
PCT/US1997/022986
Publication Date:
October 08, 1998
Filing Date:
December 22, 1997
Export Citation:
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Assignee:
ATHENA NEUROSCIENCES INC (US)
LILLY CO ELI (US)
WU JING (US)
TUNG JAY S (US)
THORSETT EUGENE D (US)
PLEISS MICHAEL A (US)
NISSEN JEFFREY S (US)
NEITZ JEFFREY (US)
LATIMER LEE H (US)
JOHN VARGHESE (US)
FREEDMAN STEPHEN (US)
BRITTON THOMAS C (US)
AUDIA JAMES E (US)
REEL JON K (US)
MABRY THOMAS E (US)
DRESSMAN BRUCE A (US)
CWI CYNTHIA L (US)
DROSTE JAMES J (US)
HENRY STEVEN S (US)
MCDANIEL STACEY L (US)
SCOTT WILLIAM LEONARD (US)
STUCKY RUSSELL D (US)
PORTER WARREN J (US)
International Classes:
A61K31/55; C07D243/16; A61K31/551; A61K31/5513; A61K31/5517; A61P25/28; A61P43/00; C07C237/22; C07D207/273; C07D211/76; C07D223/10; C07D223/16; C07D223/18; C07D243/12; C07D243/24; C07D243/38; C07D267/14; C07D281/10; C07D307/33; C07D309/30; C07D401/04; C07D401/14; C07D409/12; C07D409/14; C07D487/04; C07K5/087; C07K5/113; C07K14/18; A61K38/00; C07D207/26; C07C; (IPC1-7): C07D/
Domestic Patent References:
WO1997030072A11997-08-21
WO1995025118A21995-09-21
Foreign References:
EP0652009A11995-05-10
EP0677517A11995-10-18
FR2278335A11976-02-13
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